Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
| Location | 1686476..1687108 | Replicon | chromosome |
| Accession | NZ_CP028271 | ||
| Organism | Mixta intestinalis strain SRCM103226 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | C7M51_RS07945 | Protein ID | WP_160621299.1 |
| Coordinates | 1686932..1687108 (-) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | C7M51_RS07940 | Protein ID | WP_160621298.1 |
| Coordinates | 1686476..1686883 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C7M51_RS07900 | 1682137..1683054 | - | 918 | WP_160621290.1 | hypothetical protein | - |
| C7M51_RS07905 | 1683244..1683423 | - | 180 | WP_160621291.1 | hypothetical protein | - |
| C7M51_RS07910 | 1683530..1684045 | - | 516 | WP_160621292.1 | Rha family transcriptional regulator | - |
| C7M51_RS07915 | 1684342..1684797 | - | 456 | WP_160621293.1 | lysis protein | - |
| C7M51_RS07920 | 1684794..1685219 | - | 426 | WP_160621294.1 | lysozyme | - |
| C7M51_RS07925 | 1685206..1685547 | - | 342 | WP_160621295.1 | phage holin, lambda family | - |
| C7M51_RS07930 | 1685723..1685911 | + | 189 | WP_160621296.1 | type II toxin-antitoxin system HicA family toxin | - |
| C7M51_RS07935 | 1685975..1686385 | + | 411 | WP_160621297.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| C7M51_RS07940 | 1686476..1686883 | - | 408 | WP_160621298.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| C7M51_RS07945 | 1686932..1687108 | - | 177 | WP_160621299.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| C7M51_RS07950 | 1687297..1687872 | - | 576 | WP_160621300.1 | DUF1133 family protein | - |
| C7M51_RS07955 | 1687869..1688156 | - | 288 | WP_160621301.1 | DUF1364 domain-containing protein | - |
| C7M51_RS07960 | 1688159..1688359 | - | 201 | WP_160621302.1 | hypothetical protein | - |
| C7M51_RS07965 | 1688365..1688967 | - | 603 | WP_160621303.1 | DUF1367 family protein | - |
| C7M51_RS07970 | 1689036..1689245 | - | 210 | WP_160621304.1 | hypothetical protein | - |
| C7M51_RS07975 | 1689380..1689748 | - | 369 | WP_160621305.1 | helix-turn-helix domain-containing protein | - |
| C7M51_RS07980 | 1689875..1690540 | + | 666 | WP_160621306.1 | autoinducer binding domain-containing protein | - |
| C7M51_RS07985 | 1690706..1691101 | - | 396 | WP_160621307.1 | hypothetical protein | - |
| C7M51_RS07990 | 1691098..1691337 | - | 240 | WP_160621308.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1627765..1708875 | 81110 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6669.73 Da Isoelectric Point: 11.6500
>T100928 WP_160621299.1 NZ_CP028271:c1687108-1686932 [Mixta intestinalis]
VKQSEFRRWLESQGVEVSNGTNHLKLRHNGKRSVMPRHPGAELKEPLRKAILKQLGLN
VKQSEFRRWLESQGVEVSNGTNHLKLRHNGKRSVMPRHPGAELKEPLRKAILKQLGLN
Download Length: 177 bp
>T100928 NZ_CP028271:c1687108-1686932 [Mixta intestinalis]
GTGAAGCAAAGCGAGTTCAGGCGGTGGCTTGAATCTCAGGGAGTCGAAGTTTCAAACGGTACAAACCATCTGAAACTGAG
ACACAACGGGAAACGAAGCGTAATGCCAAGACATCCTGGAGCTGAGTTAAAAGAACCACTGCGAAAGGCCATACTCAAGC
AACTTGGCCTGAATTAA
GTGAAGCAAAGCGAGTTCAGGCGGTGGCTTGAATCTCAGGGAGTCGAAGTTTCAAACGGTACAAACCATCTGAAACTGAG
ACACAACGGGAAACGAAGCGTAATGCCAAGACATCCTGGAGCTGAGTTAAAAGAACCACTGCGAAAGGCCATACTCAAGC
AACTTGGCCTGAATTAA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14578.78 Da Isoelectric Point: 4.4335
>AT100928 WP_160621298.1 NZ_CP028271:c1686883-1686476 [Mixta intestinalis]
MRYPINLEPCDGGYVVSFPDIPEALTQGDTREEALAMGLDALITSFDFYFEDNQAVPLPGAITGDFVEVPASVASKVLLL
NAFIASGLTQVELAARMGVKKQEVTRIFDLHHSTKIDTIQKALAALGKRLELVAA
MRYPINLEPCDGGYVVSFPDIPEALTQGDTREEALAMGLDALITSFDFYFEDNQAVPLPGAITGDFVEVPASVASKVLLL
NAFIASGLTQVELAARMGVKKQEVTRIFDLHHSTKIDTIQKALAALGKRLELVAA
Download Length: 408 bp
>AT100928 NZ_CP028271:c1686883-1686476 [Mixta intestinalis]
ATGCGATACCCTATAAATCTTGAGCCGTGCGACGGCGGTTATGTGGTTTCGTTCCCCGATATACCGGAAGCGCTTACGCA
GGGCGATACGCGAGAAGAAGCGCTGGCTATGGGGCTGGATGCGCTGATTACCTCATTTGATTTCTATTTTGAGGATAATC
AGGCCGTACCACTGCCGGGGGCGATTACTGGTGATTTTGTAGAAGTTCCCGCCAGCGTGGCATCAAAAGTCCTGCTGCTT
AATGCGTTCATTGCTTCCGGCTTAACTCAGGTTGAGCTGGCGGCGCGTATGGGCGTTAAAAAGCAAGAGGTAACACGGAT
TTTCGATCTGCATCACTCAACGAAAATCGATACCATCCAAAAAGCACTGGCGGCCTTGGGTAAACGGCTTGAATTAGTTG
CTGCCTGA
ATGCGATACCCTATAAATCTTGAGCCGTGCGACGGCGGTTATGTGGTTTCGTTCCCCGATATACCGGAAGCGCTTACGCA
GGGCGATACGCGAGAAGAAGCGCTGGCTATGGGGCTGGATGCGCTGATTACCTCATTTGATTTCTATTTTGAGGATAATC
AGGCCGTACCACTGCCGGGGGCGATTACTGGTGATTTTGTAGAAGTTCCCGCCAGCGTGGCATCAAAAGTCCTGCTGCTT
AATGCGTTCATTGCTTCCGGCTTAACTCAGGTTGAGCTGGCGGCGCGTATGGGCGTTAAAAAGCAAGAGGTAACACGGAT
TTTCGATCTGCATCACTCAACGAAAATCGATACCATCCAAAAAGCACTGGCGGCCTTGGGTAAACGGCTTGAATTAGTTG
CTGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|