Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 472617..473243 Replicon chromosome
Accession NZ_CP028271
Organism Mixta intestinalis strain SRCM103226

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag C7M51_RS02130 Protein ID WP_141177081.1
Coordinates 472617..472835 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag C7M51_RS02135 Protein ID WP_160620082.1
Coordinates 472860..473243 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7M51_RS02095 468599..468937 + 339 WP_160620071.1 P-II family nitrogen regulator -
C7M51_RS02100 468972..470255 + 1284 WP_160620072.1 ammonium transporter AmtB -
C7M51_RS02105 470313..471173 - 861 WP_160620074.1 acyl-CoA thioesterase II -
C7M51_RS02110 471388..471936 + 549 WP_160620076.1 YbaY family lipoprotein -
C7M51_RS02115 471966..472277 - 312 WP_160620078.1 MGMT family protein -
C7M51_RS02120 472264..472443 - 180 WP_160620080.1 hypothetical protein -
C7M51_RS02130 472617..472835 - 219 WP_141177081.1 hemolysin expression modulator Hha Toxin
C7M51_RS02135 472860..473243 - 384 WP_160620082.1 Hha toxicity modulator TomB Antitoxin
C7M51_RS02140 473391..473744 - 354 WP_160623540.1 hypothetical protein -
C7M51_RS02145 474085..474225 - 141 WP_160620084.1 type B 50S ribosomal protein L36 -
C7M51_RS02150 474729..477878 - 3150 WP_160620086.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8685.16 Da        Isoelectric Point: 8.9007

>T100927 WP_141177081.1 NZ_CP028271:c472835-472617 [Mixta intestinalis]
MTEKLMTKTDYLMRLRRCRSIDTLERVIEKNKYELPDDELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 219 bp

>T100927 NZ_CP028271:c472835-472617 [Mixta intestinalis]
ATGACAGAAAAACTTATGACTAAGACTGACTATCTGATGCGTTTAAGACGTTGCCGATCAATTGATACGCTTGAACGAGT
GATTGAAAAAAATAAGTATGAATTACCTGACGATGAGCTGGCCGTGTTTTATTCAGCTGCCGATCACCGCCTGGCTGAAT
TAACGATGAATAAGCTGTACGATAAAGTCCCGGTGTCTGTGTGGAAATTTGTACGCTAA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 14824.43 Da        Isoelectric Point: 4.3024

>AT100927 WP_160620082.1 NZ_CP028271:c473243-472860 [Mixta intestinalis]
MDEYSPKRHDIAQLNFLCENLYDESLATLGDSHHGWVNDPTSATNLQLNELIEHIASFTMNYKIKHAEDEDLIVQIDDYL
DDTFMLFSNYGINVQDLQRWQRSARRLFNLFAEECAQLPLQPSHSFS

Download         Length: 384 bp

>AT100927 NZ_CP028271:c473243-472860 [Mixta intestinalis]
ATGGACGAATATTCACCGAAACGGCATGATATTGCCCAATTGAATTTCTTGTGTGAAAATCTGTACGACGAAAGTTTGGC
AACGCTGGGCGACAGTCATCACGGCTGGGTTAACGATCCCACTTCCGCGACCAACTTACAGCTAAATGAACTTATTGAAC
ATATTGCTTCTTTCACCATGAATTACAAAATAAAACATGCTGAAGACGAGGACCTCATCGTTCAGATTGATGATTACCTT
GATGATACTTTTATGTTATTTAGTAATTACGGCATTAATGTTCAGGATTTGCAGCGCTGGCAGCGTTCTGCCAGGCGCTT
GTTTAACCTTTTTGCAGAAGAGTGTGCTCAGCTTCCTTTACAGCCAAGCCATTCATTTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References