Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 3679609..3680525 Replicon chromosome
Accession NZ_CP028217
Organism Bacillus subtilis strain SRCM102751

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag C7M29_RS18790 Protein ID WP_017695117.1
Coordinates 3679609..3680355 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag C7M29_RS18795 Protein ID WP_003232646.1
Coordinates 3680355..3680525 (+) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7M29_RS18770 3674938..3675888 - 951 WP_161477040.1 ring-cleaving dioxygenase -
C7M29_RS18775 3676276..3677592 + 1317 WP_029317680.1 serine/threonine exchanger -
C7M29_RS18780 3677868..3678485 + 618 WP_003218470.1 DUF47 domain-containing protein -
C7M29_RS18785 3678498..3679499 + 1002 WP_014479569.1 inorganic phosphate transporter -
C7M29_RS18790 3679609..3680355 + 747 WP_017695117.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
C7M29_RS18795 3680355..3680525 + 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
C7M29_RS18800 3680611..3680748 + 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
C7M29_RS18805 3680785..3681678 - 894 WP_161477041.1 N-acetylmuramoyl-L-alanine amidase -
C7M29_RS18810 3681691..3681954 - 264 WP_003232653.1 phage holin -
C7M29_RS18815 3681967..3682236 - 270 WP_003232655.1 hemolysin XhlA family protein -
C7M29_RS18820 3682289..3683128 - 840 WP_003245597.1 phage-like element PBSX protein XepA -
C7M29_RS18825 3683172..3683336 - 165 WP_128992693.1 XkdX family protein -
C7M29_RS18830 3683333..3683662 - 330 WP_003232660.1 phage-like element PBSX protein XkdW -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3630628..3714332 83704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-238)

Antitoxin

(1-56)


Sequences


Toxin        


Download         Length: 249 a.a.        Molecular weight: 29060.56 Da        Isoelectric Point: 4.7741

>T100912 WP_017695117.1 NZ_CP028217:3679609-3680355 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWKRYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T100912 NZ_CP028217:3679609-3680355 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATTCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGAAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT100912 WP_003232646.1 NZ_CP028217:3680355-3680525 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT100912 NZ_CP028217:3680355-3680525 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References