Detailed information of TA system TA100843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 70298..70923
• Replicon: plasmid pGMI14-001
• Accession: NZ_CP028200
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN018746

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C6650_RS25340
• Protein ID: WP_000911322.1
• Coordinates: 70525..70923 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: C6650_RS25335
• Protein ID: WP_000450265.1
• Coordinates: 70298..70525 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6650_RS25335	70298..70525	+	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin
C6650_RS25340	70525..70923	+	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
C6650_RS25345	70932..73175	-	2244	WP_000009320.1	type IV conjugative transfer system coupling protein TraD	-
C6650_RS25350	73552..74283	-	732	WP_000782438.1	complement resistance protein TraT	-
C6650_RS25355	74319..74813	-	495	WP_010999946.1	entry exclusion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93933	93933

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-71)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 17065.17 Da
• Isoelectric Point: 12.9205

>T100843 WP_000911322.1 NZ_CP028200:70525-70923 [Salmonella enterica subsp. enterica serovar Typhimurium]
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KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 399 bp

>T100843 NZ_CP028200:70525-70923 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 9759.25 Da
• Isoelectric Point: 12.6750

>AT100843 WP_000450265.1 NZ_CP028200:70298-70525 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 228 bp

>AT100843 NZ_CP028200:70298-70525 [Salmonella enterica subsp. enterica serovar Typhimurium]
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