Detailed information of TA system TA100842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 42938..43463
• Replicon: plasmid pGMI14-001
• Accession: NZ_CP028200
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN018746

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: C6650_RS25170
• Protein ID: WP_001159863.1
• Coordinates: 42938..43243 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: C6650_RS25175
• Protein ID: WP_000813641.1
• Coordinates: 43245..43463 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6650_RS25130	38317..38877	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
C6650_RS25560	39033..39320	+	288	WP_071530243.1	hypothetical protein	-
C6650_RS25135	39597..40082	-	486	WP_000905606.1	membrane protein	-
C6650_RS25140	40076..40585	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
C6650_RS25150	40589..41302	-	714	Protein_52	EAL domain-containing protein	-
C6650_RS25155	41311..42093	-	783	WP_000082169.1	site-specific integrase	-
C6650_RS25160	42128..42649	-	522	WP_000198608.1	hypothetical protein	-
C6650_RS25165	42646..42936	-	291	WP_001266176.1	hypothetical protein	-
C6650_RS25170	42938..43243	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
C6650_RS25175	43245..43463	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
C6650_RS25180	44139..44660	+	522	WP_010999942.1	hypothetical protein	-
C6650_RS25190	45144..45440	+	297	WP_001687482.1	hypothetical protein	-
C6650_RS25195	45934..46923	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
C6650_RS25200	47182..47626	-	445	Protein_61	site-specific integrase	-
C6650_RS25205	47795..48176	-	382	Protein_62	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93933	93933

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (1-71)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T100842 WP_001159863.1 NZ_CP028200:c43243-42938 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T100842 NZ_CP028200:c43243-42938 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT100842 WP_000813641.1 NZ_CP028200:c43463-43245 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT100842 NZ_CP028200:c43463-43245 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6