Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4371971..4373660 Replicon chromosome
Accession NZ_CP028192
Organism Escherichia coli strain CFSAN018748

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag C7A99_RS22580 Protein ID WP_107236183.1
Coordinates 4371971..4372891 (-) Length 307 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag C7A99_RS22585 Protein ID WP_199852818.1
Coordinates 4372878..4373660 (-) Length 261 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7A99_RS22565 4368061..4369188 - 1128 WP_159042852.1 MFS transporter -
C7A99_RS22570 4369330..4370388 - 1059 WP_001586705.1 alpha/beta hydrolase -
C7A99_RS22575 4370653..4371537 + 885 WP_107236182.1 LysR family transcriptional regulator -
C7A99_RS22580 4371971..4372891 - 921 WP_107236183.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
C7A99_RS22585 4372878..4373660 - 783 WP_199852818.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
C7A99_RS22590 4374036..4374314 - 279 WP_001577780.1 helix-turn-helix domain-containing protein -
C7A99_RS22595 4374417..4374647 + 231 WP_001577779.1 helix-turn-helix domain-containing protein -
C7A99_RS22600 4374728..4374952 + 225 WP_024187424.1 helix-turn-helix domain-containing protein -
C7A99_RS22605 4375229..4376878 + 1650 WP_107236185.1 DNA phosphorothioation-dependent restriction protein DptF -
C7A99_RS22610 4376883..4378208 + 1326 WP_107236186.1 DNA phosphorothioation-dependent restriction protein DptG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4370653..4406027 35374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-261)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(3-91)


Sequences

Toxin        


Download         Length: 307 a.a.        Molecular weight: 34608.91 Da        Isoelectric Point: 6.9647

>T100832 WP_107236183.1 NZ_CP028192:c4372891-4371971 [Escherichia coli]
MDLRDSYTRQVKLLMAALPHVAKESGFALKGGTAINLFVQDFPRLSVDIDLAYKTFADRDTDLTAINDALKRITASLNSK
PGITAIRQENKTDEKRIIVNTADAQIKSEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Download         Length: 921 bp

>T100832 NZ_CP028192:c4372891-4371971 [Escherichia coli]
ATGGATCTGCGTGATAGCTATACCCGGCAGGTCAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAGTCCGGTTT
CGCATTAAAAGGCGGCACCGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATCGATCTGGCGTATA
AGACTTTTGCGGATCGCGATACCGATTTGACGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACAGTAAA
CCGGGGATTACCGCGATTCGGCAGGAAAATAAAACGGATGAAAAGCGCATCATTGTGAATACGGCTGATGCCCAGATTAA
GAGCGAGGTTAGTCCGGTCTGGCGTGGGCTATTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATCTGCGCAGCGCTTGATCGTCAGCAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGCCCCATTGCCGAGTTGCTGGCCCCAAACTGGGATACAGAGCGGATCACGACGCTGTATGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTGCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGTAATCTGGCGGTGCTGAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGCGTAA

Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29231.44 Da        Isoelectric Point: 8.2453

>AT100832 WP_199852818.1 NZ_CP028192:c4373660-4372878 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVTSLTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPREFKPEGVEDGSA

Download         Length: 783 bp

>AT100832 NZ_CP028192:c4373660-4372878 [Escherichia coli]
TTGCCAAACTATCTAAACTGGCTGATGCAGCATACACTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAACGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAGAATGGCTGGCTCAGGCGCATCGCTCACGGTGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTGCAATCGCAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGTCATGCGCACTATACCGAACAGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTTAA
GCTGCCGGGATGGTTTGCTGCCTTCGAACAATCTGCAACATTTATCACGCTGTATACATCGGGGCTTACCGTAGATGTAA
CGTCATTGACTACGGAACTGAAAATTGGCGACCGCCAGTTAGCAGGCAGTGTTCCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGTTGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCTGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCACGCGAATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References