Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1299691..1300526 Replicon chromosome
Accession NZ_CP028192
Organism Escherichia coli strain CFSAN018748

Toxin (Protein)


Gene name yeeV Uniprot ID E3PD61
Locus tag C7A99_RS06675 Protein ID WP_001094449.1
Coordinates 1299691..1300068 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A826UXU4
Locus tag C7A99_RS06680 Protein ID WP_024210939.1
Coordinates 1300158..1300526 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7A99_RS06650 1296168..1296338 - 171 Protein_1198 IS110 family transposase -
C7A99_RS06655 1296736..1298271 - 1536 WP_000492894.1 EAL domain-containing protein -
C7A99_RS06660 1298342..1299187 - 846 WP_001290172.1 DUF4942 domain-containing protein -
C7A99_RS06665 1299272..1299469 - 198 WP_087891818.1 DUF957 domain-containing protein -
C7A99_RS06670 1299545..1299694 - 150 Protein_1202 hypothetical protein -
C7A99_RS06675 1299691..1300068 - 378 WP_001094449.1 TA system toxin CbtA family protein Toxin
C7A99_RS06680 1300158..1300526 - 369 WP_024210939.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
C7A99_RS06685 1300576..1301220 - 645 WP_001079776.1 hypothetical protein -
C7A99_RS06690 1301234..1301455 - 222 WP_000692293.1 DUF987 domain-containing protein -
C7A99_RS06695 1301524..1302000 - 477 WP_001186710.1 RadC family protein -
C7A99_RS06700 1302015..1302500 - 486 WP_000206661.1 antirestriction protein -
C7A99_RS06705 1302592..1303410 - 819 WP_001234706.1 DUF945 domain-containing protein -
C7A99_RS06715 1303510..1303743 - 234 WP_001117561.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14162.00 Da        Isoelectric Point: 6.6312

>T100817 WP_001094449.1 NZ_CP028192:c1300068-1299691 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SSCTHSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T100817 NZ_CP028192:c1300068-1299691 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTAAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCAGCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13605.35 Da        Isoelectric Point: 6.4768

>AT100817 WP_024210939.1 NZ_CP028192:c1300526-1300158 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT100817 NZ_CP028192:c1300526-1300158 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCGTCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAAGGGAACCGGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTACTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PD61

Antitoxin

Source ID Structure
AlphaFold DB A0A826UXU4

References