Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 27143..28187 Replicon chromosome
Accession NZ_CP028192
Organism Escherichia coli strain CFSAN018748

Toxin (Protein)


Gene name panT Uniprot ID A0A839B4R0
Locus tag C7A99_RS00260 Protein ID WP_000019187.1
Coordinates 27143..27691 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag C7A99_RS00265 Protein ID WP_000287252.1
Coordinates 27714..28187 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7A99_RS00205 22155..22625 + 471 WP_000167585.1 hypothetical protein -
C7A99_RS00210 22776..23144 + 369 WP_025766313.1 DUF2528 family protein -
C7A99_RS27365 23217..23381 + 165 WP_134232576.1 protease FtsH-inhibitory lysogeny factor CIII -
C7A99_RS27370 23350..23463 + 114 WP_000372936.1 host cell division inhibitory peptide Kil -
C7A99_RS00220 23460..23648 + 189 WP_000613347.1 hypothetical protein -
C7A99_RS00225 23657..24337 + 681 WP_000536247.1 ATP-binding protein -
C7A99_RS00230 24334..24921 + 588 WP_001535902.1 hypothetical protein -
C7A99_RS00235 24945..25238 + 294 WP_001111298.1 DUF2856 family protein -
C7A99_RS00240 25249..25416 + 168 WP_016063110.1 DUF2737 family protein -
C7A99_RS00245 25413..26228 + 816 WP_107235456.1 ead/Ea22-like family protein -
C7A99_RS00250 26228..26800 + 573 WP_107235457.1 3'-5' exoribonuclease -
C7A99_RS00255 26837..27109 + 273 WP_001093913.1 pyocin activator PrtN family protein -
C7A99_RS00260 27143..27691 - 549 WP_000019187.1 hypothetical protein Toxin
C7A99_RS00265 27714..28187 - 474 WP_000287252.1 SocA family protein Antitoxin
C7A99_RS00270 28474..28596 - 123 WP_001300034.1 hypothetical protein -
C7A99_RS00275 28959..29923 - 965 Protein_53 DUF2713 domain-containing protein -
C7A99_RS00280 30241..30756 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
C7A99_RS00285 30798..31007 - 210 WP_001030593.1 CsbD family protein -
C7A99_RS00290 31123..32447 - 1325 Protein_56 MATE family efflux transporter DinF -
C7A99_RS00295 32520..33128 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 364..33128 32764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 19966.42 Da        Isoelectric Point: 4.5662

>T100813 WP_000019187.1 NZ_CP028192:c27691-27143 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQIFKSAFEPSNHESDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T100813 NZ_CP028192:c27691-27143 [Escherichia coli]
ATGTCTCACAATTCAGATATCTATAAACTTATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAACAGATTTTTAAATCTGCATTTGAGCCGTCTAATCATGAGAGCGACGATGATTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGCAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTTCGGACAAAAATGGCCTCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGCCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT100813 WP_000287252.1 NZ_CP028192:c28187-27714 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT100813 NZ_CP028192:c28187-27714 [Escherichia coli]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCACATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGATTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCACAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCTGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCAA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839B4R0

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References