100808

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1775771..1776248 Replicon chromosome
Accession NZ_CP028190
Organism Staphylococcus aureus strain CFSAN018749

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag C9J86_RS09170 Protein ID WP_000052076.1
Coordinates 1775771..1775959 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag C9J86_RS09175 Protein ID WP_001059690.1
Coordinates 1775988..1776248 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9J86_RS09140 1771724..1772281 + 558 WP_000824491.1 hypothetical protein -
C9J86_RS09145 1772622..1773308 + 687 WP_001574556.1 thermonuclease family protein -
C9J86_RS09150 1773665..1773865 + 201 WP_001059082.1 cold-shock protein -
C9J86_RS09155 1774362..1774580 - 219 WP_000005879.1 hypothetical protein -
C9J86_RS09160 1774642..1774926 - 285 WP_001004401.1 hypothetical protein -
C9J86_RS09165 1775014..1775583 - 570 WP_001106663.1 hypothetical protein -
C9J86_RS09170 1775771..1775959 - 189 WP_000052076.1 hypothetical protein Toxin
C9J86_RS09175 1775988..1776248 - 261 WP_001059690.1 hypothetical protein Antitoxin
C9J86_RS09180 1776589..1776792 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
C9J86_RS09185 1776789..1777025 - 237 WP_000368687.1 hypothetical protein -
C9J86_RS09190 1777250..1777831 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
C9J86_RS09195 1777904..1778521 - 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
C9J86_RS09200 1778677..1779171 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
C9J86_RS09205 1779570..1779992 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
C9J86_RS09210 1780140..1780856 + 717 WP_000150025.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T100808 WP_000052076.1 NZ_CP028190:c1775959-1775771 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T100808 NZ_CP028190:c1775959-1775771 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT100808 WP_001059690.1 NZ_CP028190:c1776248-1775988 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT100808 NZ_CP028190:c1776248-1775988 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References