100795

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2564250..2564727 Replicon chromosome
Accession NZ_CP028189
Organism Staphylococcus aureus strain CFSAN018750

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag C9J90_RS13185 Protein ID WP_000052076.1
Coordinates 2564250..2564438 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag C9J90_RS13190 Protein ID WP_001059690.1
Coordinates 2564467..2564727 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9J90_RS13155 2560285..2560761 + 477 WP_000824477.1 hypothetical protein -
C9J90_RS13160 2561102..2561788 + 687 WP_001641381.1 thermonuclease family protein -
C9J90_RS13165 2562145..2562345 + 201 WP_001059082.1 cold-shock protein -
C9J90_RS13170 2562841..2563059 - 219 WP_000005887.1 hypothetical protein -
C9J90_RS13175 2563121..2563405 - 285 WP_031590186.1 hypothetical protein -
C9J90_RS13180 2563493..2564062 - 570 WP_001106652.1 hypothetical protein -
C9J90_RS13185 2564250..2564438 - 189 WP_000052076.1 hypothetical protein Toxin
C9J90_RS13190 2564467..2564727 - 261 WP_001059690.1 hypothetical protein Antitoxin
C9J90_RS13195 2565068..2565271 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
C9J90_RS13200 2565268..2565504 - 237 WP_000368687.1 hypothetical protein -
C9J90_RS13205 2565729..2566310 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
C9J90_RS13210 2566383..2567000 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
C9J90_RS13215 2567156..2567650 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
C9J90_RS13220 2568049..2568471 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
C9J90_RS13225 2568619..2569335 + 717 WP_031589686.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-36)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T100795 WP_000052076.1 NZ_CP028189:c2564438-2564250 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T100795 NZ_CP028189:c2564438-2564250 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT100795 WP_001059690.1 NZ_CP028189:c2564727-2564467 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT100795 NZ_CP028189:c2564727-2564467 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References