Detailed information of TA system TA100787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1049847..1050376
• Replicon: chromosome
• Accession: NZ_CP028189
• Organism: Staphylococcus aureus strain CFSAN018750

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: C9J90_RS05420
• Protein ID: WP_000621175.1
• Coordinates: 1049847..1050209 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: C9J90_RS05425
• Protein ID: WP_000948331.1
• Coordinates: 1050206..1050376 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9J90_RS05395	1046825..1047595	-	771	WP_001041102.1	RNA polymerase sigma factor SigB	-
C9J90_RS05400	1047570..1048049	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
C9J90_RS05405	1048051..1048377	-	327	WP_001052491.1	anti-sigma factor antagonist	-
C9J90_RS05410	1048496..1049497	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
C9J90_RS05420	1049847..1050209	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
C9J90_RS05425	1050206..1050376	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
C9J90_RS05430	1050461..1051609	-	1149	WP_001281154.1	alanine racemase	-
C9J90_RS05435	1051675..1052034	-	360	WP_000581197.1	holo-ACP synthase	-
C9J90_RS05440	1052038..1052529	-	492	WP_072353916.1	PH domain-containing protein	-
C9J90_RS05445	1052516..1054099	-	1584	WP_001294626.1	PH domain-containing protein	-
C9J90_RS05450	1054092..1054571	-	480	WP_031590204.1	hypothetical protein	-
C9J90_RS05455	1054780..1055340	-	561	WP_001092410.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T100787 WP_000621175.1 NZ_CP028189:c1050209-1049847 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T100787 NZ_CP028189:c1050209-1049847 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT100787 WP_000948331.1 NZ_CP028189:c1050376-1050206 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT100787 NZ_CP028189:c1050376-1050206 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1