Detailed information of TA system TA100782

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 37574..38151
• Replicon: plasmid pGMI16-004
• Accession: NZ_CP028184
• Organism: Listeria monocytogenes strain CFSAN054109

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: H1G8D6
• Locus tag: C9J84_RS15995
• Protein ID: WP_003728465.1
• Coordinates: 37574..37915 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: H1G8D5
• Locus tag: C9J84_RS16000
• Protein ID: WP_003728464.1
• Coordinates: 37909..38151 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9J84_RS15985	36125..36376	+	252	WP_049955716.1	helix-turn-helix transcriptional regulator	-
C9J84_RS15990	36380..37351	+	972	WP_031641941.1	hypothetical protein	-
C9J84_RS16120	37405..37548	+	144	WP_157105793.1	hypothetical protein	-
C9J84_RS15995	37574..37915	-	342	WP_003728465.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
C9J84_RS16000	37909..38151	-	243	WP_003728464.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
C9J84_RS16005	38212..38463	-	252	WP_003728463.1	hypothetical protein	-
C9J84_RS16010	38594..38920	+	327	WP_031641563.1	hypothetical protein	-
C9J84_RS16015	38920..39582	+	663	WP_003731676.1	DUF2786 domain-containing protein	-
C9J84_RS16020	39601..39978	+	378	WP_003769263.1	DUF3850 domain-containing protein	-
C9J84_RS16025	40137..40625	+	489	WP_031669356.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..62214	62214

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 16796.15 Da
• Isoelectric Point: 5.5500

>T100782 WP_003728465.1 NZ_CP028184:c37915-37574 [Listeria monocytogenes]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 342 bp

>T100782 NZ_CP028184:c37915-37574 [Listeria monocytogenes]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 11939.32 Da
• Isoelectric Point: 5.5500

>AT100782 WP_003728464.1 NZ_CP028184:c38151-37909 [Listeria monocytogenes]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
F

Nucleotide

• Length: 243 bp

>AT100782 NZ_CP028184:c38151-37909 [Listeria monocytogenes]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTT

Structures

Toxin

• AlphaFold DB: H1G8D6

Antitoxin

• AlphaFold DB: H1G8D5