Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3015571..3016250 Replicon chromosome
Accession NZ_CP028176
Organism Klebsiella pneumoniae strain CFSAN054111

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag C9J89_RS15155 Protein ID WP_020324801.1
Coordinates 3015909..3016250 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag C9J89_RS15150 Protein ID WP_020324792.1
Coordinates 3015571..3015888 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9J89_RS15125 3010785..3013937 + 3153 WP_022631414.1 AIDA repeat-containing protein -
C9J89_RS15130 3014030..3014269 + 240 WP_020324820.1 DUF905 domain-containing protein -
C9J89_RS15135 3014372..3014830 + 459 WP_020324813.1 antirestriction protein -
C9J89_RS15140 3014846..3015322 + 477 WP_020324797.1 RadC family protein -
C9J89_RS15145 3015331..3015558 + 228 WP_020324796.1 DUF987 domain-containing protein -
C9J89_RS15150 3015571..3015888 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C9J89_RS15155 3015909..3016250 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
C9J89_RS15160 3016366..3017199 + 834 WP_020324805.1 DUF4942 domain-containing protein -
C9J89_RS15170 3017502..3018008 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
C9J89_RS15175 3018108..3019949 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA / fimI / fimC / fimD / fimD / fimF / fimG 2972716..3017199 44483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T100770 WP_020324801.1 NZ_CP028176:3015909-3016250 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T100770 NZ_CP028176:3015909-3016250 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT100770 WP_020324792.1 NZ_CP028176:3015571-3015888 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT100770 NZ_CP028176:3015571-3015888 [Klebsiella pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References