100762

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 4793..5258 Replicon plasmid pGMI17-001_2
Accession NZ_CP028174
Organism Salmonella enterica strain CFSAN064033

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag C6649_RS23940 Protein ID WP_001230707.1
Coordinates 5007..5258 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag C6649_RS23935 Protein ID WP_000801440.1
Coordinates 4793..5020 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6649_RS23885 23..238 - 216 WP_000760375.1 EexN family lipoprotein -
C6649_RS23890 235..528 - 294 WP_060598542.1 LuxR family transcriptional regulator -
C6649_RS23895 605..1834 - 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
C6649_RS23900 1838..2341 - 504 WP_000781813.1 hypothetical protein -
C6649_RS23910 2702..3049 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
C6649_RS23915 3046..3294 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
C6649_RS23920 3599..3949 - 351 WP_000854259.1 hypothetical protein -
C6649_RS23925 4040..4339 - 300 WP_000650309.1 hypothetical protein -
C6649_RS23935 4793..5020 - 228 WP_000801440.1 hypothetical protein Antitoxin
C6649_RS23940 5007..5258 - 252 WP_001230707.1 hypothetical protein Toxin
C6649_RS23945 5255..5797 - 543 WP_001083906.1 hypothetical protein -
C6649_RS24245 5902..6417 - 516 WP_001025395.1 J domain-containing protein -
C6649_RS23955 7832..8698 + 867 WP_001353743.1 replication initiation protein -
C6649_RS23960 8711..9115 + 405 WP_012421203.1 hypothetical protein -
C6649_RS23965 9250..9777 + 528 WP_000577043.1 DUF2726 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33310 33310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 12380.85 Da        Isoelectric Point: 5.5500

>T100762 WP_001230707.1 NZ_CP028174:c5258-5007 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Download         Length: 252 bp

>T100762 NZ_CP028174:c5258-5007 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 11203.44 Da        Isoelectric Point: 5.5500

>AT100762 WP_000801440.1 NZ_CP028174:c5020-4793 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 228 bp

>AT100762 NZ_CP028174:c5020-4793 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References