Detailed information of TA system
Experimentally validatedOverview
TA module
Type | II | Classification (family/domain) | hipBA/- |
Location | 3010290..3011953 | Replicon | chromosome |
Accession | NC_011916 | ||
Organism | Caulobacter crescentus NA1000 |
Toxin (Protein)
Gene name | HipA3 | Uniprot ID | A0A0H3CA56 |
Locus tag | CCNA_02858 | Protein ID | YP_002518231.1 |
Coordinates | 3010290..3011597 (-) | Length | 436 a.a. |
Antitoxin (Protein)
Gene name | HipB3 | Uniprot ID | A0A0H3CAW1 |
Locus tag | CCNA_02859 | Protein ID | YP_002518232.1 |
Coordinates | 3011594..3011953 (-) | Length | 120 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CCNA_02852 | 3005378..3006748 | - | 1371 | YP_002518225.1 | hypothetical protein | - |
CCNA_02853 | 3006909..3008306 | - | 1398 | YP_002518226.1 | two-component sensor histidine kinase | - |
CCNA_02854 | 3008437..3009114 | - | 678 | YP_002518227.1 | two-component response regulator | - |
CCNA_02855 | 3009133..3009450 | - | 318 | YP_002518228.1 | PepSY peptidase propeptide domain protein | - |
CCNA_02856 | 3009579..3010088 | - | 510 | YP_002518229.1 | hypothetical protein | - |
CCNA_02858 | 3010290..3011597 | - | 1308 | YP_002518231.1 | hipA-family phosphatidylinositol 3/4-kinase | Toxin |
CCNA_02859 | 3011594..3011953 | - | 360 | YP_002518232.1 | hypothetical protein | Antitoxin |
CCNA_02860 | 3012116..3013060 | - | 945 | YP_002518233.1 | DnaJ-class molecular chaperone | - |
CCNA_02861 | 3013149..3015680 | - | 2532 | YP_002518234.1 | glycoside hydrolase TIM-barrel-like domain-containing protein | - |
CCNA_02862 | 3015316..3016860 | - | 1545 | YP_002518235.1 | GTA glycoside hydrolase TIM-barrel domain protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 436 a.a. Molecular weight: 47909.26 Da Isoelectric Point: 6.8907
>T10076 YP_002518231.1 NC_011916:c3011597-3010290 [Caulobacter vibrioides NA1000]
MTTVAEVRLWGSRIGAVSLEDGAETAVFAYEPSFIASGIQPAPLMMPLKAGVFSFPDLPPRSFHGLPGMLADALPDKYGH
VLIDAWLATQGRSPESFNAVERLCYTGRRGMGALEFSPMAGPRRRVSSKIDIDALVTLASEVLTHRHDLRASFADADKAD
ALRDILSVGTSAGGARAKAVIAWNPATNEVRSGQVEAGAGFGYWLLKFDGVSGNRDKELADPKGYGAVEHAYGQMAAAAG
IDVAESRLLEEGGRRHFMSKRFDRLDGGGKLHMQSLAAIAHLDFNDPVANSYEQALFTMRRMGLSMAQLEEQFRRMVFNV
LARNQDDHVKNIAFLMDRAGRWRLSPAFDITWSYNPDGEWTSRHQMSINGKRDGFDFADLEACAKTASISRGHVGRIFDE
VREAVMRWPTFADAAGVDERWRDQIGATVRLELRR
MTTVAEVRLWGSRIGAVSLEDGAETAVFAYEPSFIASGIQPAPLMMPLKAGVFSFPDLPPRSFHGLPGMLADALPDKYGH
VLIDAWLATQGRSPESFNAVERLCYTGRRGMGALEFSPMAGPRRRVSSKIDIDALVTLASEVLTHRHDLRASFADADKAD
ALRDILSVGTSAGGARAKAVIAWNPATNEVRSGQVEAGAGFGYWLLKFDGVSGNRDKELADPKGYGAVEHAYGQMAAAAG
IDVAESRLLEEGGRRHFMSKRFDRLDGGGKLHMQSLAAIAHLDFNDPVANSYEQALFTMRRMGLSMAQLEEQFRRMVFNV
LARNQDDHVKNIAFLMDRAGRWRLSPAFDITWSYNPDGEWTSRHQMSINGKRDGFDFADLEACAKTASISRGHVGRIFDE
VREAVMRWPTFADAAGVDERWRDQIGATVRLELRR
Download Length: 1308 bp
>T10076 NC_011916:c3011597-3010290 [Caulobacter vibrioides NA1000]
ATGACCACCGTCGCCGAGGTTCGCCTGTGGGGCAGCCGGATCGGCGCAGTGTCGCTGGAGGACGGCGCGGAGACGGCGGT
CTTCGCCTATGAGCCGAGCTTTATCGCCAGCGGAATCCAGCCCGCCCCGCTGATGATGCCGCTGAAGGCCGGCGTGTTCA
GCTTTCCCGATCTGCCGCCGCGCAGCTTCCATGGCCTGCCCGGCATGCTGGCCGACGCCCTGCCGGACAAGTACGGCCAT
GTGCTGATCGACGCCTGGCTGGCCACGCAAGGTCGCAGCCCCGAGAGCTTCAACGCCGTCGAGCGCCTTTGCTACACCGG
CCGCCGGGGCATGGGGGCGCTGGAGTTCTCGCCGATGGCGGGGCCGCGTCGGCGGGTCTCCAGCAAGATCGACATCGACG
CCCTGGTGACCCTGGCCTCTGAGGTTCTGACCCATCGCCACGACCTGCGCGCCTCGTTCGCCGATGCGGACAAGGCCGAC
GCCCTGCGCGACATCTTGAGCGTCGGCACCTCGGCGGGCGGGGCGCGGGCCAAGGCGGTGATCGCCTGGAACCCGGCGAC
CAACGAGGTGCGCTCCGGCCAGGTCGAGGCCGGCGCGGGTTTCGGCTACTGGCTGCTGAAGTTCGACGGCGTCTCCGGCA
ACCGGGACAAGGAACTGGCCGACCCCAAGGGCTATGGCGCGGTCGAGCACGCCTATGGACAGATGGCGGCGGCGGCGGGA
ATCGACGTCGCCGAGAGTCGCTTGCTGGAGGAGGGCGGTCGTCGCCACTTCATGAGCAAGCGCTTCGACCGGCTGGACGG
CGGCGGCAAGCTGCACATGCAGTCCCTGGCCGCCATCGCTCATCTGGATTTCAACGATCCCGTCGCCAATTCCTATGAGC
AGGCCCTGTTCACCATGCGGCGGATGGGCTTGTCGATGGCGCAGCTGGAGGAGCAGTTCCGGCGCATGGTCTTCAACGTG
CTGGCGCGAAACCAGGACGACCACGTCAAGAACATCGCCTTCCTGATGGACCGCGCCGGACGCTGGCGCCTGTCGCCGGC
CTTCGACATCACCTGGAGCTACAATCCGGACGGCGAATGGACCTCGCGCCACCAGATGTCGATCAACGGCAAGCGGGACG
GGTTCGACTTCGCCGATCTCGAGGCCTGCGCGAAAACCGCCTCGATCAGTCGTGGTCACGTCGGCCGGATTTTCGATGAG
GTGCGGGAGGCCGTGATGCGGTGGCCGACCTTCGCCGACGCGGCCGGGGTGGACGAGCGCTGGCGGGATCAGATCGGCGC
TACGGTGCGGCTGGAGCTCAGGCGGTAG
ATGACCACCGTCGCCGAGGTTCGCCTGTGGGGCAGCCGGATCGGCGCAGTGTCGCTGGAGGACGGCGCGGAGACGGCGGT
CTTCGCCTATGAGCCGAGCTTTATCGCCAGCGGAATCCAGCCCGCCCCGCTGATGATGCCGCTGAAGGCCGGCGTGTTCA
GCTTTCCCGATCTGCCGCCGCGCAGCTTCCATGGCCTGCCCGGCATGCTGGCCGACGCCCTGCCGGACAAGTACGGCCAT
GTGCTGATCGACGCCTGGCTGGCCACGCAAGGTCGCAGCCCCGAGAGCTTCAACGCCGTCGAGCGCCTTTGCTACACCGG
CCGCCGGGGCATGGGGGCGCTGGAGTTCTCGCCGATGGCGGGGCCGCGTCGGCGGGTCTCCAGCAAGATCGACATCGACG
CCCTGGTGACCCTGGCCTCTGAGGTTCTGACCCATCGCCACGACCTGCGCGCCTCGTTCGCCGATGCGGACAAGGCCGAC
GCCCTGCGCGACATCTTGAGCGTCGGCACCTCGGCGGGCGGGGCGCGGGCCAAGGCGGTGATCGCCTGGAACCCGGCGAC
CAACGAGGTGCGCTCCGGCCAGGTCGAGGCCGGCGCGGGTTTCGGCTACTGGCTGCTGAAGTTCGACGGCGTCTCCGGCA
ACCGGGACAAGGAACTGGCCGACCCCAAGGGCTATGGCGCGGTCGAGCACGCCTATGGACAGATGGCGGCGGCGGCGGGA
ATCGACGTCGCCGAGAGTCGCTTGCTGGAGGAGGGCGGTCGTCGCCACTTCATGAGCAAGCGCTTCGACCGGCTGGACGG
CGGCGGCAAGCTGCACATGCAGTCCCTGGCCGCCATCGCTCATCTGGATTTCAACGATCCCGTCGCCAATTCCTATGAGC
AGGCCCTGTTCACCATGCGGCGGATGGGCTTGTCGATGGCGCAGCTGGAGGAGCAGTTCCGGCGCATGGTCTTCAACGTG
CTGGCGCGAAACCAGGACGACCACGTCAAGAACATCGCCTTCCTGATGGACCGCGCCGGACGCTGGCGCCTGTCGCCGGC
CTTCGACATCACCTGGAGCTACAATCCGGACGGCGAATGGACCTCGCGCCACCAGATGTCGATCAACGGCAAGCGGGACG
GGTTCGACTTCGCCGATCTCGAGGCCTGCGCGAAAACCGCCTCGATCAGTCGTGGTCACGTCGGCCGGATTTTCGATGAG
GTGCGGGAGGCCGTGATGCGGTGGCCGACCTTCGCCGACGCGGCCGGGGTGGACGAGCGCTGGCGGGATCAGATCGGCGC
TACGGTGCGGCTGGAGCTCAGGCGGTAG
Antitoxin
Download Length: 120 a.a. Molecular weight: 13019.91 Da Isoelectric Point: 10.1741
>AT10076 YP_002518232.1 NC_011916:c3011953-3011594 [Caulobacter vibrioides NA1000]
MKFESLLSDEAVLAEMGQRLVAARLERRLTQAQLAQAAGVSKRTVERLEDGASAQLTNLVRCLRALDRLEGLERLLPETP
ANPLDLLKQAKTGRSRVRNARASGVAETGGAPWVWGDEK
MKFESLLSDEAVLAEMGQRLVAARLERRLTQAQLAQAAGVSKRTVERLEDGASAQLTNLVRCLRALDRLEGLERLLPETP
ANPLDLLKQAKTGRSRVRNARASGVAETGGAPWVWGDEK
Download Length: 360 bp
>AT10076 NC_011916:c3011953-3011594 [Caulobacter vibrioides NA1000]
ATGAAATTTGAATCTCTCCTGTCCGATGAGGCGGTGTTGGCCGAGATGGGTCAGCGTCTGGTGGCGGCGCGGCTGGAGCG
GCGGCTGACCCAGGCTCAGCTGGCGCAGGCCGCCGGCGTATCCAAGCGCACCGTCGAGCGTCTGGAAGACGGCGCCTCGG
CCCAGCTGACCAATCTGGTGCGCTGCCTGCGGGCCCTGGACCGGCTGGAGGGGCTGGAGCGCCTGCTGCCCGAGACGCCC
GCCAATCCGCTGGACCTGCTGAAACAGGCCAAGACCGGCCGCTCAAGAGTGCGCAACGCCCGCGCGTCCGGCGTCGCCGA
GACCGGCGGCGCGCCCTGGGTGTGGGGCGATGAAAAATGA
ATGAAATTTGAATCTCTCCTGTCCGATGAGGCGGTGTTGGCCGAGATGGGTCAGCGTCTGGTGGCGGCGCGGCTGGAGCG
GCGGCTGACCCAGGCTCAGCTGGCGCAGGCCGCCGGCGTATCCAAGCGCACCGTCGAGCGTCTGGAAGACGGCGCCTCGG
CCCAGCTGACCAATCTGGTGCGCTGCCTGCGGGCCCTGGACCGGCTGGAGGGGCTGGAGCGCCTGCTGCCCGAGACGCCC
GCCAATCCGCTGGACCTGCTGAAACAGGCCAAGACCGGCCGCTCAAGAGTGCGCAACGCCCGCGCGTCCGGCGTCGCCGA
GACCGGCGGCGCGCCCTGGGTGTGGGGCGATGAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3CA56 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3CAW1 |
References
(1) Charlie Y Huang et al. (2020) hipBA toxin-antitoxin systems mediate persistence in Caulobacter crescentus. Scientific Reports 10(1):2865. [PubMed:32071324]
(2) Xiaofeng Zhou et al. (2021) A Bacterial Toxin Perturbs Intracellular Amino Acid Balance To Induce Persistence. MBio 12(1):e03020-20. [PubMed:33622732]
experimental literature