10076

Detailed information of TA system    

experimentalExperimentally validated    

Overview


TA module


Type II Classification (family/domain) hipBA/-
Location 3010290..3011953 Replicon chromosome
Accession NC_011916
Organism Caulobacter crescentus NA1000

Toxin (Protein)


Gene name HipA3 Uniprot ID A0A0H3CA56
Locus tag CCNA_02858 Protein ID YP_002518231.1
Coordinates 3010290..3011597 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID A0A0H3CAW1
Locus tag CCNA_02859 Protein ID YP_002518232.1
Coordinates 3011594..3011953 (-) Length 120 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCNA_02852 3005378..3006748 - 1371 YP_002518225.1 hypothetical protein -
CCNA_02853 3006909..3008306 - 1398 YP_002518226.1 two-component sensor histidine kinase -
CCNA_02854 3008437..3009114 - 678 YP_002518227.1 two-component response regulator -
CCNA_02855 3009133..3009450 - 318 YP_002518228.1 PepSY peptidase propeptide domain protein -
CCNA_02856 3009579..3010088 - 510 YP_002518229.1 hypothetical protein -
CCNA_02858 3010290..3011597 - 1308 YP_002518231.1 hipA-family phosphatidylinositol 3/4-kinase Toxin
CCNA_02859 3011594..3011953 - 360 YP_002518232.1 hypothetical protein Antitoxin
CCNA_02860 3012116..3013060 - 945 YP_002518233.1 DnaJ-class molecular chaperone -
CCNA_02861 3013149..3015680 - 2532 YP_002518234.1 glycoside hydrolase TIM-barrel-like domain-containing protein -
CCNA_02862 3015316..3016860 - 1545 YP_002518235.1 GTA glycoside hydrolase TIM-barrel domain protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(170-407)

Antitoxin

(17-67)


Sequences


Toxin        


Download         Length: 436 a.a.        Molecular weight: 47909.26 Da        Isoelectric Point: 6.8907

>T10076 YP_002518231.1 NC_011916:c3011597-3010290 [Caulobacter vibrioides NA1000]
MTTVAEVRLWGSRIGAVSLEDGAETAVFAYEPSFIASGIQPAPLMMPLKAGVFSFPDLPPRSFHGLPGMLADALPDKYGH
VLIDAWLATQGRSPESFNAVERLCYTGRRGMGALEFSPMAGPRRRVSSKIDIDALVTLASEVLTHRHDLRASFADADKAD
ALRDILSVGTSAGGARAKAVIAWNPATNEVRSGQVEAGAGFGYWLLKFDGVSGNRDKELADPKGYGAVEHAYGQMAAAAG
IDVAESRLLEEGGRRHFMSKRFDRLDGGGKLHMQSLAAIAHLDFNDPVANSYEQALFTMRRMGLSMAQLEEQFRRMVFNV
LARNQDDHVKNIAFLMDRAGRWRLSPAFDITWSYNPDGEWTSRHQMSINGKRDGFDFADLEACAKTASISRGHVGRIFDE
VREAVMRWPTFADAAGVDERWRDQIGATVRLELRR

Download         Length: 1308 bp

>T10076 NC_011916:c3011597-3010290 [Caulobacter vibrioides NA1000]
ATGACCACCGTCGCCGAGGTTCGCCTGTGGGGCAGCCGGATCGGCGCAGTGTCGCTGGAGGACGGCGCGGAGACGGCGGT
CTTCGCCTATGAGCCGAGCTTTATCGCCAGCGGAATCCAGCCCGCCCCGCTGATGATGCCGCTGAAGGCCGGCGTGTTCA
GCTTTCCCGATCTGCCGCCGCGCAGCTTCCATGGCCTGCCCGGCATGCTGGCCGACGCCCTGCCGGACAAGTACGGCCAT
GTGCTGATCGACGCCTGGCTGGCCACGCAAGGTCGCAGCCCCGAGAGCTTCAACGCCGTCGAGCGCCTTTGCTACACCGG
CCGCCGGGGCATGGGGGCGCTGGAGTTCTCGCCGATGGCGGGGCCGCGTCGGCGGGTCTCCAGCAAGATCGACATCGACG
CCCTGGTGACCCTGGCCTCTGAGGTTCTGACCCATCGCCACGACCTGCGCGCCTCGTTCGCCGATGCGGACAAGGCCGAC
GCCCTGCGCGACATCTTGAGCGTCGGCACCTCGGCGGGCGGGGCGCGGGCCAAGGCGGTGATCGCCTGGAACCCGGCGAC
CAACGAGGTGCGCTCCGGCCAGGTCGAGGCCGGCGCGGGTTTCGGCTACTGGCTGCTGAAGTTCGACGGCGTCTCCGGCA
ACCGGGACAAGGAACTGGCCGACCCCAAGGGCTATGGCGCGGTCGAGCACGCCTATGGACAGATGGCGGCGGCGGCGGGA
ATCGACGTCGCCGAGAGTCGCTTGCTGGAGGAGGGCGGTCGTCGCCACTTCATGAGCAAGCGCTTCGACCGGCTGGACGG
CGGCGGCAAGCTGCACATGCAGTCCCTGGCCGCCATCGCTCATCTGGATTTCAACGATCCCGTCGCCAATTCCTATGAGC
AGGCCCTGTTCACCATGCGGCGGATGGGCTTGTCGATGGCGCAGCTGGAGGAGCAGTTCCGGCGCATGGTCTTCAACGTG
CTGGCGCGAAACCAGGACGACCACGTCAAGAACATCGCCTTCCTGATGGACCGCGCCGGACGCTGGCGCCTGTCGCCGGC
CTTCGACATCACCTGGAGCTACAATCCGGACGGCGAATGGACCTCGCGCCACCAGATGTCGATCAACGGCAAGCGGGACG
GGTTCGACTTCGCCGATCTCGAGGCCTGCGCGAAAACCGCCTCGATCAGTCGTGGTCACGTCGGCCGGATTTTCGATGAG
GTGCGGGAGGCCGTGATGCGGTGGCCGACCTTCGCCGACGCGGCCGGGGTGGACGAGCGCTGGCGGGATCAGATCGGCGC
TACGGTGCGGCTGGAGCTCAGGCGGTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13019.91 Da        Isoelectric Point: 10.1741

>AT10076 YP_002518232.1 NC_011916:c3011953-3011594 [Caulobacter vibrioides NA1000]
MKFESLLSDEAVLAEMGQRLVAARLERRLTQAQLAQAAGVSKRTVERLEDGASAQLTNLVRCLRALDRLEGLERLLPETP
ANPLDLLKQAKTGRSRVRNARASGVAETGGAPWVWGDEK

Download         Length: 360 bp

>AT10076 NC_011916:c3011953-3011594 [Caulobacter vibrioides NA1000]
ATGAAATTTGAATCTCTCCTGTCCGATGAGGCGGTGTTGGCCGAGATGGGTCAGCGTCTGGTGGCGGCGCGGCTGGAGCG
GCGGCTGACCCAGGCTCAGCTGGCGCAGGCCGCCGGCGTATCCAAGCGCACCGTCGAGCGTCTGGAAGACGGCGCCTCGG
CCCAGCTGACCAATCTGGTGCGCTGCCTGCGGGCCCTGGACCGGCTGGAGGGGCTGGAGCGCCTGCTGCCCGAGACGCCC
GCCAATCCGCTGGACCTGCTGAAACAGGCCAAGACCGGCCGCTCAAGAGTGCGCAACGCCCGCGCGTCCGGCGTCGCCGA
GACCGGCGGCGCGCCCTGGGTGTGGGGCGATGAAAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3CA56


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3CAW1

References


(1) Charlie Y Huang et al. (2020) hipBA toxin-antitoxin systems mediate persistence in Caulobacter crescentus. Scientific Reports 10(1):2865. [PubMed:32071324] experimental

(2) Xiaofeng Zhou et al. (2021) A Bacterial Toxin Perturbs Intracellular Amino Acid Balance To Induce Persistence. MBio 12(1):e03020-20. [PubMed:33622732] experimental


experimental experimental literature