Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2387296..2387773 Replicon chromosome
Accession NZ_CP028165
Organism Staphylococcus aureus strain CFSAN064037

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag C9J78_RS12050 Protein ID WP_000052076.1
Coordinates 2387296..2387484 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag C9J78_RS12055 Protein ID WP_001059690.1
Coordinates 2387513..2387773 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9J78_RS12020 2383335..2383805 + 471 WP_000824470.1 hypothetical protein -
C9J78_RS12025 2384146..2384832 + 687 WP_001804081.1 thermonuclease family protein -
C9J78_RS12030 2385189..2385389 + 201 WP_001059082.1 cold-shock protein -
C9J78_RS12035 2385887..2386105 - 219 WP_000005880.1 hypothetical protein -
C9J78_RS12040 2386167..2386451 - 285 WP_001004401.1 hypothetical protein -
C9J78_RS12045 2386539..2387108 - 570 WP_001106650.1 hypothetical protein -
C9J78_RS12050 2387296..2387484 - 189 WP_000052076.1 hypothetical protein Toxin
C9J78_RS12055 2387513..2387773 - 261 WP_001059690.1 hypothetical protein Antitoxin
C9J78_RS12060 2388114..2388317 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
C9J78_RS12065 2388314..2388550 - 237 WP_000368687.1 hypothetical protein -
C9J78_RS12070 2388775..2389356 + 582 WP_001140691.1 phosphoglycerate mutase family protein -
C9J78_RS12075 2389429..2390046 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
C9J78_RS12080 2390202..2390696 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
C9J78_RS12085 2391095..2391517 - 423 WP_000974454.1 organic hydroperoxide resistance protein -
C9J78_RS12090 2391665..2392381 + 717 WP_000150031.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T100726 WP_000052076.1 NZ_CP028165:c2387484-2387296 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T100726 NZ_CP028165:c2387484-2387296 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT100726 WP_001059690.1 NZ_CP028165:c2387773-2387513 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT100726 NZ_CP028165:c2387773-2387513 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATAAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References