Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 871719..872233 Replicon chromosome
Accession NZ_CP028165
Organism Staphylococcus aureus strain CFSAN064037

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag C9J78_RS04530 Protein ID WP_000603099.1
Coordinates 871719..871928 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag C9J78_RS04535 Protein ID WP_000138933.1
Coordinates 871940..872233 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9J78_RS04510 867227..868585 - 1359 WP_103145520.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
C9J78_RS04515 868600..869670 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
C9J78_RS04520 869988..871190 + 1203 WP_107240654.1 rod shape-determining protein RodA -
C9J78_RS04525 871454..871591 - 138 WP_000828354.1 hypothetical protein -
C9J78_RS04530 871719..871928 - 210 WP_000603099.1 heavy-metal-associated domain-containing protein Toxin
C9J78_RS04535 871940..872233 - 294 WP_000138933.1 copper-sensing transcriptional repressor CsoR Antitoxin
C9J78_RS04540 872399..873883 + 1485 WP_000571551.1 cardiolipin synthase -
C9J78_RS04545 873911..874573 + 663 WP_001187618.1 HD domain-containing protein -
C9J78_RS04560 875324..876196 - 873 WP_000725802.1 membrane protein insertase YidC -
C9J78_RS04565 876282..876923 - 642 WP_000483158.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7819.79 Da        Isoelectric Point: 3.9389

>T100722 WP_000603099.1 NZ_CP028165:c871928-871719 [Staphylococcus aureus]
MILQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T100722 NZ_CP028165:c871928-871719 [Staphylococcus aureus]
ATGATACTTCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.81 Da        Isoelectric Point: 6.7122

>AT100722 WP_000138933.1 NZ_CP028165:c872233-871940 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNKGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT100722 NZ_CP028165:c872233-871940 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATAAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References