Detailed information of TA system TA100720

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 798052..798590
• Replicon: chromosome
• Accession: NZ_CP028165
• Organism: Staphylococcus aureus strain CFSAN064037

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: C9J78_RS04145
• Protein ID: WP_103145483.1
• Coordinates: 798052..798378 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: C5QLS5
• Locus tag: C9J78_RS04150
• Protein ID: WP_001058489.1
• Coordinates: 798381..798590 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9J78_RS04120	793377..793718	-	342	WP_001190600.1	hypothetical protein	-
C9J78_RS04125	794065..794706	-	642	WP_103145487.1	pathogenicity island protein	-
C9J78_RS04130	794703..795083	-	381	WP_103145486.1	hypothetical protein	-
C9J78_RS04135	795393..797102	-	1710	WP_103145485.1	DUF927 domain-containing protein	-
C9J78_RS04140	797116..797985	-	870	WP_103145484.1	primase C-terminal domain-containing protein	-
C9J78_RS04145	798052..798378	-	327	WP_103145483.1	DUF1474 family protein	Toxin
C9J78_RS04150	798381..798590	-	210	WP_001058489.1	hypothetical protein	Antitoxin
C9J78_RS04155	798583..798729	-	147	WP_000784893.1	hypothetical protein	-
C9J78_RS04160	798726..799043	-	318	WP_103145482.1	helix-turn-helix domain-containing protein	-
C9J78_RS04165	799047..799259	-	213	WP_103145481.1	helix-turn-helix transcriptional regulator	-
C9J78_RS04170	799422..800099	+	678	WP_103145480.1	helix-turn-helix transcriptional regulator	-
C9J78_RS04175	800116..801288	+	1173	WP_103145479.1	site-specific integrase	-
C9J78_RS04180	801357..802973	-	1617	WP_000240646.1	chaperonin GroEL	-
C9J78_RS04185	803048..803332	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / groEL	773723..806354	32631

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13044.45 Da
• Isoelectric Point: 4.6844

>T100720 WP_103145483.1 NZ_CP028165:c798378-798052 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFDNFYPHEPNHVLNKTEAIKEGLSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDAQKLKITE

Nucleotide

• Length: 327 bp

>T100720 NZ_CP028165:c798378-798052 [Staphylococcus aureus]
ATGAATTGGGAAATTAATGATTTGTTTAGCGATTTGAAAGTGTTGAAAGATAGATTCGAAGATTTAAAGGATAATCATGG
TTGGCATTTTGATAATTTTTATCCTCATGAACCTAATCATGTTTTAAATAAAACCGAAGCGATTAAAGAAGGACTTTCTT
ATCACGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACCGAATCAGATGACGCGCAGAAATTAAAAATTAC
AGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8225.24 Da
• Isoelectric Point: 4.2820

>AT100720 WP_001058489.1 NZ_CP028165:c798590-798381 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT100720 NZ_CP028165:c798590-798381 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A853V601