Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsaAT/- |
Location | 2477879..2478355 | Replicon | chromosome |
Accession | NZ_CP028163 | ||
Organism | Staphylococcus aureus strain CFSAN064038 |
Toxin (Protein)
Gene name | TsaT | Uniprot ID | T1Y7S2 |
Locus tag | C9J77_RS12910 | Protein ID | WP_000052076.1 |
Coordinates | 2478167..2478355 (+) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | TsaA | Uniprot ID | T1Y6P8 |
Locus tag | C9J77_RS12905 | Protein ID | WP_001059690.1 |
Coordinates | 2477879..2478139 (+) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C9J77_RS12870 | 2473277..2473993 | - | 717 | WP_000150026.1 | type I 3-dehydroquinate dehydratase | - |
C9J77_RS12875 | 2474141..2474563 | + | 423 | WP_074371006.1 | organic hydroperoxide resistance protein | - |
C9J77_RS12880 | 2474962..2475456 | + | 495 | WP_000569881.1 | GNAT family N-acetyltransferase | - |
C9J77_RS12885 | 2475605..2476222 | + | 618 | WP_000255562.1 | LysE/ArgO family amino acid transporter | - |
C9J77_RS12890 | 2476295..2476876 | - | 582 | WP_001140696.1 | phosphoglycerate mutase family protein | - |
C9J77_RS12895 | 2477101..2477337 | + | 237 | WP_000368687.1 | hypothetical protein | - |
C9J77_RS12900 | 2477334..2477537 | - | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
C9J77_RS12905 | 2477879..2478139 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
C9J77_RS12910 | 2478167..2478355 | + | 189 | WP_000052076.1 | hypothetical protein | Toxin |
C9J77_RS12915 | 2478543..2479112 | + | 570 | WP_001106655.1 | hypothetical protein | - |
C9J77_RS12920 | 2479200..2479484 | + | 285 | WP_001004403.1 | hypothetical protein | - |
C9J77_RS12925 | 2479545..2479763 | + | 219 | WP_000005881.1 | hypothetical protein | - |
C9J77_RS12930 | 2480260..2480460 | - | 201 | WP_001059082.1 | cold-shock protein | - |
C9J77_RS12935 | 2480817..2481503 | - | 687 | WP_001574556.1 | thermonuclease family protein | - |
C9J77_RS12940 | 2481844..2482326 | - | 483 | WP_000824489.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T100716 WP_000052076.1 NZ_CP028163:2478167-2478355 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T100716 NZ_CP028163:2478167-2478355 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT100716 WP_001059690.1 NZ_CP028163:2477879-2478139 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT100716 NZ_CP028163:2477879-2478139 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VP18 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VN56 |