Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2477879..2478355 Replicon chromosome
Accession NZ_CP028163
Organism Staphylococcus aureus strain CFSAN064038

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag C9J77_RS12910 Protein ID WP_000052076.1
Coordinates 2478167..2478355 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag C9J77_RS12905 Protein ID WP_001059690.1
Coordinates 2477879..2478139 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9J77_RS12870 2473277..2473993 - 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -
C9J77_RS12875 2474141..2474563 + 423 WP_074371006.1 organic hydroperoxide resistance protein -
C9J77_RS12880 2474962..2475456 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
C9J77_RS12885 2475605..2476222 + 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
C9J77_RS12890 2476295..2476876 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
C9J77_RS12895 2477101..2477337 + 237 WP_000368687.1 hypothetical protein -
C9J77_RS12900 2477334..2477537 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
C9J77_RS12905 2477879..2478139 + 261 WP_001059690.1 hypothetical protein Antitoxin
C9J77_RS12910 2478167..2478355 + 189 WP_000052076.1 hypothetical protein Toxin
C9J77_RS12915 2478543..2479112 + 570 WP_001106655.1 hypothetical protein -
C9J77_RS12920 2479200..2479484 + 285 WP_001004403.1 hypothetical protein -
C9J77_RS12925 2479545..2479763 + 219 WP_000005881.1 hypothetical protein -
C9J77_RS12930 2480260..2480460 - 201 WP_001059082.1 cold-shock protein -
C9J77_RS12935 2480817..2481503 - 687 WP_001574556.1 thermonuclease family protein -
C9J77_RS12940 2481844..2482326 - 483 WP_000824489.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T100716 WP_000052076.1 NZ_CP028163:2478167-2478355 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T100716 NZ_CP028163:2478167-2478355 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT100716 WP_001059690.1 NZ_CP028163:2477879-2478139 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT100716 NZ_CP028163:2477879-2478139 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References