100715

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1594316..1595424 Replicon chromosome
Accession NZ_CP028163
Organism Staphylococcus aureus strain CFSAN064038

Toxin (Protein)


Gene name MNTss Uniprot ID A0A0M4MHJ8
Locus tag C9J77_RS08385 Protein ID WP_002303392.1
Coordinates 1594555..1595424 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID B9DSK1
Locus tag C9J77_RS08380 Protein ID WP_002303393.1
Coordinates 1594316..1594540 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9J77_RS08360 1589317..1589880 + 564 Protein_1538 recombinase zinc beta ribbon domain-containing protein -
C9J77_RS08365 1590323..1591807 + 1485 WP_074371031.1 ABC-F type ribosomal protection protein Lsa(E) -
C9J77_RS08370 1591861..1592664 + 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
C9J77_RS08375 1593352..1594173 + 822 Protein_1541 recombinase zinc beta ribbon domain-containing protein -
C9J77_RS08380 1594316..1594540 + 225 WP_002303393.1 helix-turn-helix transcriptional regulator Antitoxin
C9J77_RS08385 1594555..1595424 + 870 WP_002303392.1 nucleotidyltransferase domain-containing protein Toxin
C9J77_RS08390 1595456..1596091 + 636 WP_074347692.1 methyltransferase domain-containing protein -
C9J77_RS08395 1596326..1596472 + 147 Protein_1545 hypothetical protein -
C9J77_RS08400 1596540..1596824 + 285 WP_000171859.1 hypothetical protein -
C9J77_RS08405 1596941..1597138 - 198 WP_000025835.1 hypothetical protein -
C9J77_RS08410 1597298..1597771 + 474 WP_001236734.1 DUF4930 family protein -
C9J77_RS08415 1597845..1597964 + 120 WP_000840603.1 hypothetical protein -
C9J77_RS08420 1598162..1599004 + 843 WP_000911033.1 rod shape-determining protein MreC -
C9J77_RS08425 1599004..1599534 + 531 WP_001259929.1 rod shape-determining protein MreD -
C9J77_RS08430 1600021..1600329 + 309 WP_000457386.1 50S ribosomal protein L21 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island lsa(E) / lnu(B) - 1589446..1597771 8325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32807.38 Da        Isoelectric Point: 4.7269

>T100715 WP_002303392.1 NZ_CP028163:1594555-1595424 [Staphylococcus aureus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

>T100715 NZ_CP028163:1594555-1595424 [Staphylococcus aureus]
ATGGTAGGTAATGTTATTCAAATAGTAACAGAGAAATTATCATCTTTGCCTTTTATAGAAGGCATTGTATTAGGGGGCTC
ACGTGCAAGAAGCACCCATACAGAAAATTCTGATATAGATATCGGAATCTATTACAATTCAGACTCATTTGACCTGACAG
CGATTAATCAAATTGCTACAGAGTTGGATGATGAGAATAGAAACAACCTTGTTGTACCTCCCGGAGCGTGGGGTGATTGG
GTTAATGGCGGTGGATGGTTAGTTATAAACGGGTGTCATGTTGACTTGATATTACGTGATATAAAACGGGTGGAACAAAT
AATCAAAGATACGGAGCAAGGAATTGTTACTGCCAATTATCAGACCGGGCATCCCCATGGTTATATAAGTGCTATGTATC
GTGGAGAATTAGCGATTAGTAAAATACTATATGCTAAGAACGAAAGCTTATGCGAATTAAAAAAGCAGGCAGAAATTTAC
CCTACTGCTCTAAAGAAAAGCTTGATGAACTTTTTTATATTTGAAGCTGAATTCTCTTTAATGTTTGTAAAAGCAAATGC
GGGGGCAGAGGATAAATATTATATTGCAGGCCATGTTTTTCGTATTATTTCATGCTTAAATCAAGTACTATTTGCATGTA
ATAATGCTTATTGCATTAACGAAAAGAAAGCTATAAAACTGCTTGAAACTTTTGAATATAAACCTGAAAAATATGCCGAA
AGAGTTAATCATATTTTTGAAGTACTCGGTCTTTCTCTTTTTGAATGCTACGACATGACCGAGAAACTTTATAAAGAAGT
GAATGAAATTGTATCGGAGATAAATAACTTTTTAAACGAGGAGAGTTCAGATGAAAGAAAACAAATATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8351.65 Da        Isoelectric Point: 4.5357

>AT100715 WP_002303393.1 NZ_CP028163:1594316-1594540 [Staphylococcus aureus]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE

Download         Length: 225 bp

>AT100715 NZ_CP028163:1594316-1594540 [Staphylococcus aureus]
ATGACTACGGCAGAAATGATTAAAGAACTGTGTGAGCAAATGAATATAAGTGTTTCCGAACTTGCTAGACGTATTGGCCA
GACTCCACAGAATTTCAATAAAAAATTACAACGAGAAACAGTAACCTTGGATGAGTTGAAGGCCATTGCTGATGTGCTAG
GTGTCAAGTTTGTGCAGGCATTTATTTTACCAGATGGAGATGAAATAAAAATATCTAACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4MHJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A1M5SHM7

References