Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 136429..137217 Replicon chromosome
Accession NZ_CP028163
Organism Staphylococcus aureus strain CFSAN064038

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag C9J77_RS00855 Protein ID WP_000525004.1
Coordinates 136756..137217 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag C9J77_RS00850 Protein ID WP_000333630.1
Coordinates 136429..136743 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9J77_RS00790 131571..132737 - 1167 WP_031794996.1 DUF2800 domain-containing protein -
C9J77_RS00795 132734..133096 - 363 WP_000985976.1 hypothetical protein -
C9J77_RS00800 133111..133434 - 324 WP_000174994.1 hypothetical protein -
C9J77_RS00805 133513..133674 - 162 WP_001285948.1 DUF1270 domain-containing protein -
C9J77_RS00810 133687..133950 - 264 WP_016187436.1 helix-turn-helix domain-containing protein -
C9J77_RS00815 133975..134190 - 216 WP_001097552.1 hypothetical protein -
C9J77_RS00820 134245..134610 + 366 WP_016170627.1 hypothetical protein -
C9J77_RS00825 134579..134824 - 246 WP_001025401.1 DUF2829 domain-containing protein -
C9J77_RS00830 134880..135089 + 210 WP_000642492.1 hypothetical protein -
C9J77_RS00835 135079..135222 - 144 WP_000939498.1 hypothetical protein -
C9J77_RS00840 135251..136027 - 777 WP_001148544.1 Rha family transcriptional regulator -
C9J77_RS00845 136041..136277 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
C9J77_RS00850 136429..136743 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
C9J77_RS00855 136756..137217 + 462 WP_000525004.1 hypothetical protein Toxin
C9J77_RS00860 137235..137819 + 585 WP_031918390.1 hypothetical protein -
C9J77_RS00865 138050..138196 + 147 WP_074370993.1 hypothetical protein -
C9J77_RS00870 138193..138807 - 615 WP_000191466.1 hypothetical protein -
C9J77_RS00875 138933..140138 + 1206 WP_031795352.1 site-specific integrase -
C9J77_RS00880 140232..142166 - 1935 Protein_164 YSIRK domain-containing triacylglycerol lipase Lip2/Geh -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - geh 94924..149382 54458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T100702 WP_000525004.1 NZ_CP028163:136756-137217 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T100702 NZ_CP028163:136756-137217 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT100702 WP_000333630.1 NZ_CP028163:136429-136743 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT100702 NZ_CP028163:136429-136743 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References