Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
Location | 136429..137217 | Replicon | chromosome |
Accession | NZ_CP028163 | ||
Organism | Staphylococcus aureus strain CFSAN064038 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A2I7Y5B3 |
Locus tag | C9J77_RS00855 | Protein ID | WP_000525004.1 |
Coordinates | 136756..137217 (+) | Length | 154 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A0E7YIA0 |
Locus tag | C9J77_RS00850 | Protein ID | WP_000333630.1 |
Coordinates | 136429..136743 (+) | Length | 105 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C9J77_RS00790 | 131571..132737 | - | 1167 | WP_031794996.1 | DUF2800 domain-containing protein | - |
C9J77_RS00795 | 132734..133096 | - | 363 | WP_000985976.1 | hypothetical protein | - |
C9J77_RS00800 | 133111..133434 | - | 324 | WP_000174994.1 | hypothetical protein | - |
C9J77_RS00805 | 133513..133674 | - | 162 | WP_001285948.1 | DUF1270 domain-containing protein | - |
C9J77_RS00810 | 133687..133950 | - | 264 | WP_016187436.1 | helix-turn-helix domain-containing protein | - |
C9J77_RS00815 | 133975..134190 | - | 216 | WP_001097552.1 | hypothetical protein | - |
C9J77_RS00820 | 134245..134610 | + | 366 | WP_016170627.1 | hypothetical protein | - |
C9J77_RS00825 | 134579..134824 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
C9J77_RS00830 | 134880..135089 | + | 210 | WP_000642492.1 | hypothetical protein | - |
C9J77_RS00835 | 135079..135222 | - | 144 | WP_000939498.1 | hypothetical protein | - |
C9J77_RS00840 | 135251..136027 | - | 777 | WP_001148544.1 | Rha family transcriptional regulator | - |
C9J77_RS00845 | 136041..136277 | - | 237 | WP_001121027.1 | helix-turn-helix domain-containing protein | - |
C9J77_RS00850 | 136429..136743 | + | 315 | WP_000333630.1 | helix-turn-helix domain-containing protein | Antitoxin |
C9J77_RS00855 | 136756..137217 | + | 462 | WP_000525004.1 | hypothetical protein | Toxin |
C9J77_RS00860 | 137235..137819 | + | 585 | WP_031918390.1 | hypothetical protein | - |
C9J77_RS00865 | 138050..138196 | + | 147 | WP_074370993.1 | hypothetical protein | - |
C9J77_RS00870 | 138193..138807 | - | 615 | WP_000191466.1 | hypothetical protein | - |
C9J77_RS00875 | 138933..140138 | + | 1206 | WP_031795352.1 | site-specific integrase | - |
C9J77_RS00880 | 140232..142166 | - | 1935 | Protein_164 | YSIRK domain-containing triacylglycerol lipase Lip2/Geh | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | geh | 94924..149382 | 54458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T100702 WP_000525004.1 NZ_CP028163:136756-137217 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T100702 NZ_CP028163:136756-137217 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT100702 WP_000333630.1 NZ_CP028163:136429-136743 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT100702 NZ_CP028163:136429-136743 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2I7Y5B3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E7YIA0 |