Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 2531062..2532462 Replicon chromosome
Accession NZ_CP028160
Organism Lactococcus lactis subsp. lactis strain 14B4

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag LL14B4_RS12590 Protein ID WP_109991357.1
Coordinates 2531818..2532462 (-) Length 215 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID -
Locus tag LL14B4_RS12585 Protein ID WP_109991356.1
Coordinates 2531062..2531814 (-) Length 251 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL14B4_RS12560 2526667..2527293 + 627 WP_012898725.1 signal peptidase I -
LL14B4_RS12565 2527342..2528157 - 816 WP_010906422.1 pur operon repressor -
LL14B4_RS12575 2529248..2530246 + 999 WP_109991354.1 IS30 family transposase -
LL14B4_RS12580 2530427..2530963 + 537 WP_109991355.1 hypothetical protein -
LL14B4_RS12585 2531062..2531814 - 753 WP_109991356.1 DUF4065 domain-containing protein Antitoxin
LL14B4_RS12590 2531818..2532462 - 645 WP_109991357.1 hypothetical protein Toxin
LL14B4_RS12595 2532735..2533160 - 426 WP_109991358.1 DUF1761 domain-containing protein -
LL14B4_RS12600 2533244..2534584 - 1341 WP_109991359.1 LysM peptidoglycan-binding domain-containing protein -
LL14B4_RS12605 2534581..2534931 - 351 WP_109991360.1 holin -
LL14B4_RS12610 2534980..2536266 - 1287 WP_109991361.1 pyocin knob domain-containing protein -
LL14B4_RS12615 2536276..2537394 - 1119 WP_109991362.1 siphovirus ReqiPepy6 Gp37-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2529248..2565535 36287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(112-225)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 25076.43 Da        Isoelectric Point: 6.3499

>T100691 WP_109991357.1 NZ_CP028160:c2532462-2531818 [Lactococcus lactis subsp. lactis]
MEQETDSYSEVNNLIREINNLHKVFSLGIEDFLNYNLKKSVRSVVDETGINRDFLILINKYKIALNAGVSSFLDVQINFP
SVRYRIKQGESISEKILYYMTANHEYGGVPLNKCLNDFLGFRILVSDLDSLYERLMSDNDLKGVVKLLLREDGPYRGLHL
YFKNGKNKFFPWELQIWDKSQAEQNELSHSEHKQKRKYISLAQTYYDGNLEKEE

Download         Length: 645 bp

>T100691 NZ_CP028160:c2532462-2531818 [Lactococcus lactis subsp. lactis]
TTGGAGCAGGAGACCGATTCATACTCAGAAGTTAATAATCTCATACGTGAAATCAATAATCTGCATAAAGTTTTTTCTCT
TGGGATAGAAGATTTTTTAAATTATAATTTAAAGAAAAGTGTTAGGTCGGTAGTGGATGAGACAGGTATTAATCGCGATT
TTCTTATTCTAATAAATAAGTACAAAATTGCTTTAAATGCTGGTGTGAGTAGTTTTTTAGATGTACAAATTAATTTTCCT
AGTGTCAGGTACCGCATAAAACAAGGTGAATCCATTAGTGAAAAAATACTTTATTATATGACTGCTAACCATGAGTATGG
TGGGGTTCCTTTAAATAAATGCTTGAATGATTTTCTCGGATTTAGAATATTAGTATCCGACTTAGATAGCCTTTACGAAC
GTTTAATGAGTGATAATGATTTGAAAGGTGTTGTGAAACTACTTTTAAGGGAAGATGGACCCTACAGAGGTCTGCATTTA
TATTTTAAGAATGGGAAGAATAAGTTTTTTCCCTGGGAACTACAAATTTGGGACAAAAGTCAAGCGGAACAAAACGAATT
GTCTCACAGTGAACACAAGCAGAAACGCAAGTATATTTCACTGGCTCAAACTTATTACGATGGAAATTTAGAAAAGGAGG
AATAG

Antitoxin


Download         Length: 251 a.a.        Molecular weight: 29156.45 Da        Isoelectric Point: 4.8934

>AT100691 WP_109991356.1 NZ_CP028160:c2531814-2531062 [Lactococcus lactis subsp. lactis]
MYQHFILIASSYTEGTRIGFHLSAEKQIEKSIIEDKMMRISQIKRDDVGVHSFMTDSQDWESVIKLDSFFEDVIVCPSFE
KFEEALMFDSKISAIDVAKFFLAVKPMSHLKIQKLVYLAYKEYLFKYRGSLFEEKIVAYKYGPVVEEVYQTFKEYGADEI
KIDDDKDNTDYILKDIHLPQAMGRMLLAKDVEKIVPTLLKVVKEYGDFSGGQLVDLTHSEKGPWDTVYKPYYNREITDEV
ILSQAEHEKF

Download         Length: 753 bp

>AT100691 NZ_CP028160:c2531814-2531062 [Lactococcus lactis subsp. lactis]
ATGTATCAACATTTTATATTAATTGCGAGTTCATACACAGAGGGTACAAGAATTGGTTTTCATTTATCGGCAGAAAAACA
AATAGAAAAAAGTATCATAGAAGATAAGATGATGAGAATCAGCCAAATTAAACGAGATGATGTTGGTGTTCATTCTTTTA
TGACTGATAGTCAAGATTGGGAAAGTGTTATTAAGCTAGATTCCTTCTTTGAAGATGTTATAGTATGTCCAAGCTTTGAA
AAATTTGAAGAAGCCTTGATGTTTGATTCGAAAATTTCAGCTATAGATGTGGCTAAGTTTTTTTTGGCAGTTAAACCCAT
GTCTCACTTAAAAATACAAAAATTAGTTTATCTGGCTTATAAAGAATATCTTTTTAAGTATCGAGGTTCACTATTTGAAG
AAAAAATAGTTGCTTACAAATATGGACCCGTGGTAGAGGAAGTATACCAAACATTTAAAGAGTATGGTGCAGATGAAATC
AAAATAGATGATGATAAAGATAATACAGATTATATTTTAAAGGATATACACTTACCACAAGCTATGGGAAGAATGCTATT
AGCTAAAGATGTAGAAAAAATCGTTCCTACTTTATTGAAAGTAGTAAAAGAATATGGTGATTTTAGTGGTGGGCAATTAG
TTGATTTAACTCATTCAGAAAAAGGACCATGGGATACGGTTTATAAACCATATTATAATCGTGAAATAACTGATGAAGTG
ATTCTTTCTCAAGCAGAACATGAAAAATTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References