Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 2531062..2532462 Replicon chromosome
Accession NZ_CP028160
Organism Lactococcus lactis subsp. lactis strain 14B4

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag LL14B4_RS12590 Protein ID WP_109991357.1
Coordinates 2531818..2532462 (-) Length 215 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID -
Locus tag LL14B4_RS12585 Protein ID WP_109991356.1
Coordinates 2531062..2531814 (-) Length 251 a.a.

Genomic Context

LL14B4_RS12560LL14B4_RS12575LL14B4_RS12580LL14B4_RS12565LL14B4_RS12585LL14B4_RS12590LL14B4_RS12595LL14B4_RS12600LL14B4_RS12605LL14B4_RS12610LL14B4_RS12615
Location: 2526667..2527293 (627 bp)
Type: Others
Protein ID: WP_012898725.1
Location: 2529248..2530246 (999 bp)
Type: Others
Protein ID: WP_109991354.1
Location: 2530427..2530963 (537 bp)
Type: Others
Protein ID: WP_109991355.1
Location: 2527342..2528157 (816 bp)
Type: Others
Protein ID: WP_010906422.1
Location: 2531062..2531814 (753 bp)
Type: Antitoxin
Protein ID: WP_109991356.1
Location: 2531818..2532462 (645 bp)
Type: Toxin
Protein ID: WP_109991357.1
Location: 2532735..2533160 (426 bp)
Type: Others
Protein ID: WP_109991358.1
Location: 2533244..2534584 (1341 bp)
Type: Others
Protein ID: WP_109991359.1
Location: 2534581..2534931 (351 bp)
Type: Others
Protein ID: WP_109991360.1
Location: 2534980..2536266 (1287 bp)
Type: Others
Protein ID: WP_109991361.1
Location: 2536276..2537394 (1119 bp)
Type: Others
Protein ID: WP_109991362.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LL14B4_RS125602526667..2527293+627WP_012898725.1signal peptidase I-
LL14B4_RS125652527342..2528157-816WP_010906422.1pur operon repressor-
LL14B4_RS125752529248..2530246+999WP_109991354.1IS30 family transposase-
LL14B4_RS125802530427..2530963+537WP_109991355.1hypothetical protein-
LL14B4_RS125852531062..2531814-753WP_109991356.1DUF4065 domain-containing proteinAntitoxin
LL14B4_RS125902531818..2532462-645WP_109991357.1hypothetical proteinToxin
LL14B4_RS125952532735..2533160-426WP_109991358.1DUF1761 domain-containing protein-
LL14B4_RS126002533244..2534584-1341WP_109991359.1LysM peptidoglycan-binding domain-containing protein-
LL14B4_RS126052534581..2534931-351WP_109991360.1holin-
LL14B4_RS126102534980..2536266-1287WP_109991361.1pyocin knob domain-containing protein-
LL14B4_RS126152536276..2537394-1119WP_109991362.1siphovirus ReqiPepy6 Gp37-like family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2529248..256553536287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(112-225)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 25076.43 Da        Isoelectric Point: 6.3499

>T100691 WP_109991357.1 NZ_CP028160:c2532462-2531818 [Lactococcus lactis subsp. lactis]
MEQETDSYSEVNNLIREINNLHKVFSLGIEDFLNYNLKKSVRSVVDETGINRDFLILINKYKIALNAGVSSFLDVQINFP
SVRYRIKQGESISEKILYYMTANHEYGGVPLNKCLNDFLGFRILVSDLDSLYERLMSDNDLKGVVKLLLREDGPYRGLHL
YFKNGKNKFFPWELQIWDKSQAEQNELSHSEHKQKRKYISLAQTYYDGNLEKEE

Download         Length: 645 bp

>T100691 NZ_CP028160:c2532462-2531818 [Lactococcus lactis subsp. lactis]
TTGGAGCAGGAGACCGATTCATACTCAGAAGTTAATAATCTCATACGTGAAATCAATAATCTGCATAAAGTTTTTTCTCT
TGGGATAGAAGATTTTTTAAATTATAATTTAAAGAAAAGTGTTAGGTCGGTAGTGGATGAGACAGGTATTAATCGCGATT
TTCTTATTCTAATAAATAAGTACAAAATTGCTTTAAATGCTGGTGTGAGTAGTTTTTTAGATGTACAAATTAATTTTCCT
AGTGTCAGGTACCGCATAAAACAAGGTGAATCCATTAGTGAAAAAATACTTTATTATATGACTGCTAACCATGAGTATGG
TGGGGTTCCTTTAAATAAATGCTTGAATGATTTTCTCGGATTTAGAATATTAGTATCCGACTTAGATAGCCTTTACGAAC
GTTTAATGAGTGATAATGATTTGAAAGGTGTTGTGAAACTACTTTTAAGGGAAGATGGACCCTACAGAGGTCTGCATTTA
TATTTTAAGAATGGGAAGAATAAGTTTTTTCCCTGGGAACTACAAATTTGGGACAAAAGTCAAGCGGAACAAAACGAATT
GTCTCACAGTGAACACAAGCAGAAACGCAAGTATATTTCACTGGCTCAAACTTATTACGATGGAAATTTAGAAAAGGAGG
AATAG

Antitoxin


Download         Length: 251 a.a.        Molecular weight: 29156.45 Da        Isoelectric Point: 4.8934

>AT100691 WP_109991356.1 NZ_CP028160:c2531814-2531062 [Lactococcus lactis subsp. lactis]
MYQHFILIASSYTEGTRIGFHLSAEKQIEKSIIEDKMMRISQIKRDDVGVHSFMTDSQDWESVIKLDSFFEDVIVCPSFE
KFEEALMFDSKISAIDVAKFFLAVKPMSHLKIQKLVYLAYKEYLFKYRGSLFEEKIVAYKYGPVVEEVYQTFKEYGADEI
KIDDDKDNTDYILKDIHLPQAMGRMLLAKDVEKIVPTLLKVVKEYGDFSGGQLVDLTHSEKGPWDTVYKPYYNREITDEV
ILSQAEHEKF

Download         Length: 753 bp

>AT100691 NZ_CP028160:c2531814-2531062 [Lactococcus lactis subsp. lactis]
ATGTATCAACATTTTATATTAATTGCGAGTTCATACACAGAGGGTACAAGAATTGGTTTTCATTTATCGGCAGAAAAACA
AATAGAAAAAAGTATCATAGAAGATAAGATGATGAGAATCAGCCAAATTAAACGAGATGATGTTGGTGTTCATTCTTTTA
TGACTGATAGTCAAGATTGGGAAAGTGTTATTAAGCTAGATTCCTTCTTTGAAGATGTTATAGTATGTCCAAGCTTTGAA
AAATTTGAAGAAGCCTTGATGTTTGATTCGAAAATTTCAGCTATAGATGTGGCTAAGTTTTTTTTGGCAGTTAAACCCAT
GTCTCACTTAAAAATACAAAAATTAGTTTATCTGGCTTATAAAGAATATCTTTTTAAGTATCGAGGTTCACTATTTGAAG
AAAAAATAGTTGCTTACAAATATGGACCCGTGGTAGAGGAAGTATACCAAACATTTAAAGAGTATGGTGCAGATGAAATC
AAAATAGATGATGATAAAGATAATACAGATTATATTTTAAAGGATATACACTTACCACAAGCTATGGGAAGAATGCTATT
AGCTAAAGATGTAGAAAAAATCGTTCCTACTTTATTGAAAGTAGTAAAAGAATATGGTGATTTTAGTGGTGGGCAATTAG
TTGATTTAACTCATTCAGAAAAAGGACCATGGGATACGGTTTATAAACCATATTATAATCGTGAAATAACTGATGAAGTG
ATTCTTTCTCAAGCAGAACATGAAAAATTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References