Detailed information of TA system TA100689

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 4615348..4615919
• Replicon: chromosome
• Accession: NZ_CP028158
• Organism: Plantactinospora sp. BC1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C6361_RS20225
• Protein ID: WP_199853516.1
• Coordinates: 4615348..4615608 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C6361_RS20230
• Protein ID: WP_107268659.1
• Coordinates: 4615635..4615919 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6361_RS20195	4610553..4611929	+	1377	WP_107260590.1	cystathionine beta-synthase	-
C6361_RS20200	4611967..4612923	-	957	WP_107268657.1	trypsin-like peptidase domain-containing protein	-
C6361_RS20205	4613030..4613557	-	528	WP_107268658.1	GNAT family N-acetyltransferase	-
C6361_RS20210	4613614..4613913	+	300	WP_199853027.1	MmcQ/YjbR family DNA-binding protein	-
C6361_RS20215	4613873..4614856	-	984	WP_107271056.1	ribonuclease Z	-
C6361_RS20220	4615229..4615315	-	87	Protein_3999	peptide-methionine (S)-S-oxide reductase	-
C6361_RS20225	4615348..4615608	-	261	WP_199853516.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C6361_RS20230	4615635..4615919	-	285	WP_107268659.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
C6361_RS20235	4616014..4616673	-	660	WP_107268660.1	peptide-methionine (S)-S-oxide reductase MsrA	-
C6361_RS20240	4616871..4617437	+	567	WP_199853517.1	hypothetical protein	-
C6361_RS20245	4617427..4617840	-	414	WP_107268662.1	HIT family protein	-
C6361_RS20250	4617864..4619006	+	1143	WP_107268663.1	cystathionine gamma-synthase	-
C6361_RS20255	4619054..4620454	+	1401	WP_107260569.1	amidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (24-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9650.05 Da
• Isoelectric Point: 9.9738

>T100689 WP_199853516.1 NZ_CP028158:c4615608-4615348 [Plantactinospora sp. BC1]
MQVAGPAARALAGRLPEKIAAAVYEFITTALLDNPHRVGKRLLLPPFQGTWSARRGTYRVLYEIDEDDRVVTVTAIEHRA
DAYRSR

Nucleotide

• Length: 261 bp

>T100689 NZ_CP028158:c4615608-4615348 [Plantactinospora sp. BC1]
CTGCAGGTCGCCGGGCCGGCCGCACGCGCCTTGGCCGGGCGGCTGCCAGAGAAGATCGCCGCAGCCGTCTACGAGTTCAT
CACCACCGCCCTCCTCGACAACCCGCATCGCGTCGGCAAACGACTGCTTCTGCCACCGTTCCAGGGAACCTGGTCGGCCA
GACGGGGCACGTATCGAGTCCTCTACGAGATCGACGAGGACGACCGCGTCGTGACCGTGACGGCCATAGAACATCGCGCC
GACGCCTACCGGTCGCGTTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10144.43 Da
• Isoelectric Point: 4.4537

>AT100689 WP_107268659.1 NZ_CP028158:c4615919-4615635 [Plantactinospora sp. BC1]
MTVVPFTDARNRLSELIDEVTSTHERIEITKHGHTAAVLISADDLAALEETLEVLSSAEAMRQLAESKAAVEAGDVLDAD
ELAALMAKRSKQAR

Nucleotide

• Length: 285 bp

>AT100689 NZ_CP028158:c4615919-4615635 [Plantactinospora sp. BC1]
ATGACTGTCGTGCCCTTCACCGACGCTCGCAACCGCCTCTCAGAACTCATCGACGAGGTGACCTCGACCCATGAGCGGAT
AGAGATCACCAAACACGGCCACACCGCCGCGGTACTCATCTCCGCCGACGATCTCGCGGCTTTGGAAGAGACGCTGGAGG
TCCTGTCCAGCGCTGAAGCCATGCGGCAACTTGCCGAATCCAAGGCAGCCGTCGAAGCCGGTGACGTTCTCGACGCCGAC
GAACTCGCGGCGTTGATGGCGAAGCGGTCGAAGCAGGCACGGTGA