Detailed information of TA system TA100685

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/Xre(antitoxin)
• Location: 7334..7835
• Replicon: plasmid pRM2968-2
• Accession: NZ_CP028153
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis str. RM2968

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: Q9F571
• Locus tag: SEEERM2968_RS24260
• Protein ID: WP_000702246.1
• Coordinates: 7334..7594 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: -
• Locus tag: SEEERM2968_RS24265
• Protein ID: WP_001132407.1
• Coordinates: 7584..7835 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEERM2968_RS24210	2926..3087	+	162	WP_001434039.1	type I toxin-antitoxin system Hok family toxin	-
SEEERM2968_RS24215	3237..3833	+	597	WP_000125166.1	hypothetical protein	-
SEEERM2968_RS24900	3851..4135	-	285	WP_001162371.1	hypothetical protein	-
SEEERM2968_RS24225	4214..4879	-	666	WP_000532148.1	P-loop NTPase	-
SEEERM2968_RS24235	5477..5806	+	330	WP_000855118.1	hypothetical protein	-
SEEERM2968_RS24245	6387..6710	+	324	WP_000427402.1	hypothetical protein	-
SEEERM2968_RS24250	6752..6961	+	210	WP_000866037.1	hypothetical protein	-
SEEERM2968_RS24255	7059..7283	+	225	WP_000814384.1	hypothetical protein	-
SEEERM2968_RS24260	7334..7594	+	261	WP_000702246.1	hypothetical protein	Toxin
SEEERM2968_RS24265	7584..7835	+	252	WP_001132407.1	transcriptional regulator	Antitoxin
SEEERM2968_RS24280	8385..8663	+	279	WP_000545937.1	hypothetical protein	-
SEEERM2968_RS24285	9094..9360	+	267	WP_000681608.1	type II toxin-antitoxin system HicB family antitoxin	-
SEEERM2968_RS24290	9467..9649	-	183	WP_001481829.1	hypothetical protein	-
SEEERM2968_RS24295	10207..10389	+	183	WP_000833470.1	type II toxin-antitoxin system HicA family toxin	-
SEEERM2968_RS24300	10414..10851	+	438	WP_000466318.1	type II toxin-antitoxin system HicB family antitoxin	-
SEEERM2968_RS24305	10982..11437	-	456	WP_000206705.1	hypothetical protein	-
SEEERM2968_RS24310	11457..12056	-	600	WP_000091423.1	hypothetical protein	-
SEEERM2968_RS24315	12103..12804	-	702	WP_000280995.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..60294	60294

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 11169.16 Da
• Isoelectric Point: 12.7344

>T100685 WP_000702246.1 NZ_CP028153:7334-7594 [Salmonella enterica subsp. enterica serovar Enteritidis str. RM2968]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKK

Nucleotide

• Length: 261 bp

>T100685 NZ_CP028153:7334-7594 [Salmonella enterica subsp. enterica serovar Enteritidis str. RM2968]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT100685 WP_001132407.1 NZ_CP028153:7584-7835 [Salmonella enterica subsp. enterica serovar Enteritidis str. RM2968]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT100685 NZ_CP028153:7584-7835 [Salmonella enterica subsp. enterica serovar Enteritidis str. RM2968]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A3E1XBA7