Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 16746..17271 Replicon plasmid pRM2968-1
Accession NZ_CP028152
Organism Salmonella enterica subsp. enterica serovar Enteritidis str. RM2968

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag SEEERM2968_RS23940 Protein ID WP_001159863.1
Coordinates 16966..17271 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag SEEERM2968_RS23935 Protein ID WP_000813641.1
Coordinates 16746..16964 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEEERM2968_RS23905 12360..12746 + 387 WP_000751876.1 YgiW/YdeI family stress tolerance OB fold protein -
SEEERM2968_RS23910 12799..12960 + 162 WP_015059604.1 hypothetical protein -
SEEERM2968_RS23915 13287..14276 - 990 WP_000461382.1 RepB family plasmid replication initiator protein -
SEEERM2968_RS23920 14770..15065 - 296 Protein_23 cytoplasmic protein -
SEEERM2968_RS24885 15077..15505 + 429 Protein_24 hypothetical protein -
SEEERM2968_RS23930 15549..16070 - 522 WP_077681952.1 hypothetical protein -
SEEERM2968_RS23935 16746..16964 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
SEEERM2968_RS23940 16966..17271 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
SEEERM2968_RS23945 17273..17563 + 291 WP_001266176.1 hypothetical protein -
SEEERM2968_RS23950 17560..18081 + 522 WP_000198608.1 hypothetical protein -
SEEERM2968_RS23955 18116..18898 + 783 WP_000082169.1 site-specific integrase -
SEEERM2968_RS23960 18907..19620 + 714 WP_000545756.1 EAL domain-containing protein -
SEEERM2968_RS23965 19624..20133 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
SEEERM2968_RS23970 20127..20612 + 486 WP_000905606.1 membrane protein -
SEEERM2968_RS23975 20889..21176 - 288 WP_071530243.1 hypothetical protein -
SEEERM2968_RS23980 21332..21892 + 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..56636 56636


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T100684 WP_001159863.1 NZ_CP028152:16966-17271 [Salmonella enterica subsp. enterica serovar Enteritidis str. RM2968]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T100684 NZ_CP028152:16966-17271 [Salmonella enterica subsp. enterica serovar Enteritidis str. RM2968]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT100684 WP_000813641.1 NZ_CP028152:16746-16964 [Salmonella enterica subsp. enterica serovar Enteritidis str. RM2968]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT100684 NZ_CP028152:16746-16964 [Salmonella enterica subsp. enterica serovar Enteritidis str. RM2968]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References