Detailed information of TA system TA100683

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1700835..1701447
• Replicon: chromosome
• Accession: NZ_CP028148
• Organism: Streptococcus pyogenes strain TJ11-001

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q1JJZ2
• Locus tag: C9I27_RS08800
• Protein ID: WP_002988077.1
• Coordinates: 1701112..1701447 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: C9I27_RS08795
• Protein ID: WP_002988079.1
• Coordinates: 1700835..1701122 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9I27_RS08770	1696026..1697009	-	984	WP_002988088.1	tagatose-bisphosphate aldolase	-
C9I27_RS08775	1697013..1697942	-	930	WP_002988085.1	tagatose-6-phosphate kinase	-
C9I27_RS08780	1697988..1698503	-	516	WP_002988082.1	galactose-6-phosphate isomerase subunit LacB	-
C9I27_RS08785	1698538..1698966	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
C9I27_RS08790	1699412..1700185	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
C9I27_RS08795	1700835..1701122	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
C9I27_RS08800	1701112..1701447	+	336	WP_002988077.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C9I27_RS10070	1701599..1702069	+	471	WP_002988074.1	integrase	-
C9I27_RS10075	1702032..1702394	+	363	WP_180373113.1	tyrosine-type recombinase/integrase	-
C9I27_RS10080	1702430..1702579	+	150	WP_002982720.1	hypothetical protein	-
C9I27_RS08810	1702699..1703091	-	393	WP_002982716.1	30S ribosomal protein S9	-
C9I27_RS08815	1703112..1703558	-	447	WP_002982710.1	50S ribosomal protein L13	-
C9I27_RS08820	1703776..1703982	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
C9I27_RS08825	1703979..1704485	-	507	WP_002988070.1	hypothetical protein	-
C9I27_RS08830	1704621..1705481	-	861	WP_002982687.1	DegV family protein	-
C9I27_RS08835	1705578..1706096	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13117.83 Da
• Isoelectric Point: 5.2144

>T100683 WP_002988077.1 NZ_CP028148:1701112-1701447 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T100683 NZ_CP028148:1701112-1701447 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT100683 WP_002988079.1 NZ_CP028148:1700835-1701122 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT100683 NZ_CP028148:1700835-1701122 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A660A236

Antitoxin

• AlphaFold DB: A0A4U7GX94