Detailed information of TA system TA100680

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1546168..1546780
• Replicon: chromosome
• Accession: NZ_CP028140
• Organism: Streptococcus pyogenes strain NGAS979

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4Z2JY48
• Locus tag: C5P47_RS07865
• Protein ID: WP_002982731.1
• Coordinates: 1546445..1546780 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: C5P47_RS07860
• Protein ID: WP_002988079.1
• Coordinates: 1546168..1546455 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5P47_RS07835	1541389..1542372	-	984	WP_032464565.1	tagatose-bisphosphate aldolase	-
C5P47_RS07840	1542376..1543305	-	930	WP_032464566.1	tagatose-6-phosphate kinase	-
C5P47_RS07845	1543351..1543866	-	516	WP_011285170.1	galactose-6-phosphate isomerase subunit LacB	-
C5P47_RS07850	1543901..1544329	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
C5P47_RS07855	1544745..1545518	+	774	WP_002993783.1	DeoR/GlpR family DNA-binding transcription regulator	-
C5P47_RS07860	1546168..1546455	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
C5P47_RS07865	1546445..1546780	+	336	WP_002982731.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C5P47_RS09150	1546932..1547402	+	471	Protein_1448	integrase	-
C5P47_RS07880	1547365..1547913	+	549	WP_109828874.1	site-specific integrase	-
C5P47_RS07885	1548033..1548425	-	393	WP_002982716.1	30S ribosomal protein S9	-
C5P47_RS07890	1548446..1548892	-	447	WP_002982710.1	50S ribosomal protein L13	-
C5P47_RS07895	1549110..1549316	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
C5P47_RS07900	1549313..1549819	-	507	WP_002988070.1	hypothetical protein	-
C5P47_RS07905	1549955..1550815	-	861	WP_011529009.1	DegV family protein	-
C5P47_RS07910	1550912..1551430	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.88 Da
• Isoelectric Point: 5.2144

>T100680 WP_002982731.1 NZ_CP028140:1546445-1546780 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T100680 NZ_CP028140:1546445-1546780 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT100680 WP_002988079.1 NZ_CP028140:1546168-1546455 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT100680 NZ_CP028140:1546168-1546455 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A4Z2JY48

Antitoxin

• AlphaFold DB: A0A4U7GX94