Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3245129..3245782 Replicon chromosome
Accession NZ_CP028138
Organism Acinetobacter baumannii strain NCIMB 8209

Toxin (Protein)


Gene name cptA Uniprot ID A0A2S4T466
Locus tag C4X49_RS15845 Protein ID WP_000607071.1
Coordinates 3245129..3245518 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID N9LG27
Locus tag C4X49_RS15850 Protein ID WP_001288212.1
Coordinates 3245525..3245782 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4X49_RS15825 3240736..3241944 + 1209 WP_000343018.1 IS256-like element ISAba26 family transposase -
C4X49_RS15830 3241976..3242443 - 468 Protein_3057 hypothetical protein -
C4X49_RS15835 3242631..3243197 - 567 WP_000651536.1 rhombosortase -
C4X49_RS15840 3243275..3244342 - 1068 WP_130089812.1 hypothetical protein -
C4X49_RS15845 3245129..3245518 - 390 WP_000607071.1 membrane protein Toxin
C4X49_RS15850 3245525..3245782 - 258 WP_001288212.1 succinate dehydrogenase assembly factor 2 Antitoxin
C4X49_RS15855 3245970..3247142 + 1173 WP_130089813.1 acyl-CoA dehydrogenase family protein -
C4X49_RS15860 3247189..3248679 - 1491 WP_005134653.1 NAD(P)/FAD-dependent oxidoreductase -
C4X49_RS15865 3248861..3249238 - 378 WP_001216380.1 50S ribosomal protein L17 -
C4X49_RS15870 3249257..3250264 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3240736..3241944 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T100677 WP_000607071.1 NZ_CP028138:c3245518-3245129 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T100677 NZ_CP028138:c3245518-3245129 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTACTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10332.79 Da        Isoelectric Point: 4.6247

>AT100677 WP_001288212.1 NZ_CP028138:c3245782-3245525 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKAEPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT100677 NZ_CP028138:c3245782-3245525 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGAGCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4T466

Antitoxin

Source ID Structure
AlphaFold DB N9LG27

References