Detailed information of TA system TA100676

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-RelB
• Location: 124608..125121
• Replicon: chromosome
• Accession: NZ_CP028138
• Organism: Acinetobacter baumannii strain NCIMB 8209

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: S7WT01
• Locus tag: C4X49_RS00605
• Protein ID: WP_004907133.1
• Coordinates: 124608..124871 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S7WSW9
• Locus tag: C4X49_RS00610
• Protein ID: WP_000557943.1
• Coordinates: 124858..125121 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4X49_RS00565	120480..120689	+	210	Protein_106	IS3 family transposase	-
C4X49_RS00570	120726..121031	+	306	WP_000122230.1	IS630 transposase-related protein	-
C4X49_RS00575	121070..121573	+	504	WP_106631126.1	IS630 family transposase	-
C4X49_RS00580	121578..121951	+	374	Protein_109	IS3 family transposase	-
C4X49_RS00585	122033..122779	+	747	WP_130089689.1	IS5 family transposase	-
C4X49_RS00590	122812..123461	+	650	Protein_111	IS3 family transposase	-
C4X49_RS00595	123742..124335	+	594	Protein_112	IS5 family transposase	-
C4X49_RS00600	124381..124536	+	156	Protein_113	IS5/IS1182 family transposase	-
C4X49_RS00605	124608..124871	-	264	WP_004907133.1	Txe/YoeB family addiction module toxin	Toxin
C4X49_RS00610	124858..125121	-	264	WP_000557943.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
C4X49_RS00615	125538..128885	+	3348	WP_130089690.1	DEAD/DEAH box helicase	-
C4X49_RS00620	128904..129596	-	693	WP_213075342.1	HipA domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	113945..158662	44717

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10650.07 Da
• Isoelectric Point: 8.4894

>T100676 WP_004907133.1 NZ_CP028138:c124871-124608 [Acinetobacter baumannii]
MTSRNVEWTENAWDEYIYWQTQDKKILKRINTLIRECQRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISI
VQCRFHY

Nucleotide

• Length: 264 bp

>T100676 NZ_CP028138:c124871-124608 [Acinetobacter baumannii]
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATAAAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGAAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
GTTCAATGTCGGTTCCATTACTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9841.04 Da
• Isoelectric Point: 5.5940

>AT100676 WP_000557943.1 NZ_CP028138:c125121-124858 [Acinetobacter baumannii]
MHVFTYTDARNNLKSVLDKVIDDADVAFITRKEGGHAVVMGQDHYDSLMETLYLLSSPNNTTRLNESIAQLRAGKTKQRE
LIKDDES

Nucleotide

• Length: 264 bp

>AT100676 NZ_CP028138:c125121-124858 [Acinetobacter baumannii]
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGTGGTCATGCTGTAGTAATGGGACAAGATCATTACGACAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA

Structures

Toxin

• AlphaFold DB: S7WT01

Antitoxin

• AlphaFold DB: S7WSW9