Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3374077..3375650 Replicon chromosome
Accession NZ_CP028133
Organism Aeromonas veronii strain 17ISAe

Toxin (Protein)


Gene name hipA Uniprot ID A0A2R7QC79
Locus tag C7U63_RS15735 Protein ID WP_042013336.1
Coordinates 3374331..3375650 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1Q8D8F6
Locus tag C7U63_RS15730 Protein ID WP_042013334.1
Coordinates 3374077..3374331 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7U63_RS15695 3369423..3369770 - 348 WP_000679427.1 quaternary ammonium compound efflux SMR transporter QacE delta 1 -
C7U63_RS15700 3369993..3370445 - 453 WP_001749986.1 NAD(+)--rifampin ADP-ribosyltransferase Arr-3 -
C7U63_RS15705 3370542..3371096 - 555 WP_063840321.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr5 -
C7U63_RS15710 3371388..3372401 + 1014 WP_000845048.1 class 1 integron integrase IntI1 -
C7U63_RS15720 3373037..3373486 + 450 WP_075112290.1 nucleotidyltransferase domain-containing protein -
C7U63_RS15725 3373479..3373907 + 429 WP_075112289.1 DUF86 domain-containing protein -
C7U63_RS15730 3374077..3374331 + 255 WP_042013334.1 helix-turn-helix domain-containing protein Antitoxin
C7U63_RS15735 3374331..3375650 + 1320 WP_042013336.1 type II toxin-antitoxin system HipA family toxin Toxin
C7U63_RS15740 3376072..3378054 - 1983 WP_107683434.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
C7U63_RS15745 3378051..3378935 - 885 WP_107683435.1 ABC transporter substrate-binding protein -
C7U63_RS15750 3378970..3379734 - 765 WP_107683436.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul1 / qacE / tet(A) / ARR-3 / aac(6')-Ib-cr - 3349743..3375650 25907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49396.41 Da        Isoelectric Point: 7.0149

>T100674 WP_042013336.1 NZ_CP028133:3374331-3375650 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDGELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITEIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDAISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

>T100674 NZ_CP028133:3374331-3375650 [Aeromonas veronii]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCATGGCTGGCACAACCGGGCAGCCGTCCCATCTCACTTTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACTCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGACGTTCCAGATGTCAGGCGAATCGACTACAAAGCACTTTCCGATGGCGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGAGCGCAAGAAAAGACAGCG
CTGCTCTATCTCGATGGCCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATTGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGTCATGGAGGACCAGGGATCACTGAAATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCAGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAATACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCAAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGTGTTACCCAGCAATTGCCAGCGGGCTTCCCCGATGCCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9323.64 Da        Isoelectric Point: 7.9834

>AT100674 WP_042013334.1 NZ_CP028133:3374077-3374331 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILASLELSLDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp

>AT100674 NZ_CP028133:3374077-3374331 [Aeromonas veronii]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAACTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCATCACTCGAATTGTCACTGGACATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R7QC79

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8D8F6

References