Detailed information of TA system TA100668

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 142684..143189
• Replicon: chromosome
• Accession: NZ_CP028132
• Organism: Pseudomonas aeruginosa strain YB01

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: C7T90_RS00640
• Protein ID: WP_003083773.1
• Coordinates: 142684..142965 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: C7T90_RS00645
• Protein ID: WP_003083775.1
• Coordinates: 142962..143189 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7T90_RS00615	137935..139284	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
C7T90_RS00620	139333..140019	+	687	WP_003083762.1	FadR family transcriptional regulator	-
C7T90_RS00625	140120..140854	+	735	WP_003117208.1	GntR family transcriptional regulator	-
C7T90_RS00630	141058..141444	+	387	WP_014602345.1	aegerolysin family protein	-
C7T90_RS00635	141476..142384	-	909	WP_003083769.1	LysR family transcriptional regulator	-
C7T90_RS00640	142684..142965	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
C7T90_RS00645	142962..143189	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
C7T90_RS00650	143365..143985	-	621	WP_003101226.1	hypothetical protein	-
C7T90_RS00655	144086..144586	+	501	WP_003101228.1	LEA type 2 family protein	-
C7T90_RS00660	144659..145000	+	342	WP_023081666.1	alkylphosphonate utilization protein	-
C7T90_RS00665	145100..145684	-	585	WP_073674849.1	DUF4276 family protein	-
C7T90_RS00670	145681..146889	-	1209	WP_023081665.1	AAA family ATPase	-
C7T90_RS00675	147281..147394	+	114	Protein_136	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	147281..147397	116

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T100668 WP_003083773.1 NZ_CP028132:c142965-142684 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T100668 NZ_CP028132:c142965-142684 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATTGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT100668 WP_003083775.1 NZ_CP028132:c143189-142962 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT100668 NZ_CP028132:c143189-142962 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9