Detailed information of TA system TA100665

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2343209..2343883
• Replicon: chromosome
• Accession: NZ_CP028127
• Organism: Xanthomonas vasicola pv. vasculorum strain SAM119

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A837APC7
• Locus tag: C7V42_RS10855
• Protein ID: WP_010373126.1
• Coordinates: 2343464..2343883 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A837APP1
• Locus tag: C7V42_RS10850
• Protein ID: WP_010373123.1
• Coordinates: 2343209..2343463 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7V42_RS10815	2338389..2338604	-	216	WP_010370235.1	hypothetical protein	-
C7V42_RS10820	2339162..2339524	+	363	WP_087910995.1	CopG family transcriptional regulator	-
C7V42_RS10825	2339626..2340621	+	996	WP_087910994.1	DUF4935 domain-containing protein	-
C7V42_RS10830	2341077..2341523	+	447	WP_017115703.1	hypothetical protein	-
C7V42_RS10835	2341588..2341779	+	192	WP_010373115.1	hypothetical protein	-
C7V42_RS10840	2342035..2343009	-	975	WP_199285780.1	DUF2326 domain-containing protein	-
C7V42_RS10850	2343209..2343463	+	255	WP_010373123.1	plasmid stabilization protein	Antitoxin
C7V42_RS10855	2343464..2343883	+	420	WP_010373126.1	type II toxin-antitoxin system VapC family toxin	Toxin
C7V42_RS10860	2344053..2344838	+	786	WP_087910997.1	P-type conjugative transfer protein TrbJ	-
C7V42_RS10865	2344854..2345129	+	276	WP_017115702.1	entry exclusion lipoprotein TrbK	-
C7V42_RS10870	2345126..2346760	+	1635	WP_010373135.1	P-type conjugative transfer protein TrbL	-
C7V42_RS10875	2346827..2347054	+	228	WP_010373138.1	type I toxin-antitoxin system ptaRNA1 family toxin	-
C7V42_RS10880	2347294..2347653	-	360	WP_010373141.1	hypothetical protein	-
C7V42_RS10885	2347828..2348409	+	582	WP_017122811.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2273963..2360774	86811

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15049.13 Da
• Isoelectric Point: 4.5762

>T100665 WP_010373126.1 NZ_CP028127:2343464-2343883 [Xanthomonas vasicola pv. vasculorum]
MIVLDTNVVSEAMKPEPDAAVRAWLNDQAAETLYLSSVTLAELLFGIRALPAGKRKNMLDRALTELLELFKDRVLPFDTD
AARHYADLAVTAKNGGRGFPTPDGYIAAVAASRGFIVASRDTSPYEAAGVNVINPWEDV

Nucleotide

• Length: 420 bp

>T100665 NZ_CP028127:2343464-2343883 [Xanthomonas vasicola pv. vasculorum]
ATGATCGTCCTGGATACCAACGTCGTTTCAGAGGCGATGAAGCCGGAGCCGGACGCGGCCGTGAGGGCCTGGCTGAACGA
CCAAGCGGCGGAAACCTTGTACCTGTCCAGCGTCACGCTGGCCGAGTTGCTGTTTGGCATCCGGGCGCTGCCGGCGGGCA
AGCGCAAGAACATGCTCGACCGCGCTCTGACCGAGCTGCTGGAACTGTTCAAGGATCGGGTCTTGCCGTTCGATACGGAT
GCAGCGCGCCACTATGCCGACCTGGCCGTGACGGCCAAGAACGGCGGGCGCGGCTTCCCGACGCCAGACGGCTACATCGC
GGCCGTTGCAGCCTCGCGGGGCTTCATCGTGGCATCGCGCGACACATCGCCCTATGAAGCGGCTGGCGTGAATGTCATCA
ACCCTTGGGAGGATGTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9274.71 Da
• Isoelectric Point: 10.5807

>AT100665 WP_010373123.1 NZ_CP028127:2343209-2343463 [Xanthomonas vasicola pv. vasculorum]
MAILTVRNVPDDVHRALRVRAAQHGRSTEAEVREILAAVVKPEKRVRVGEALAAIGRKIGLTNEDFAVFESVRDKTPAKP
LSFE

Nucleotide

• Length: 255 bp

>AT100665 NZ_CP028127:2343209-2343463 [Xanthomonas vasicola pv. vasculorum]
ATGGCAATTCTGACTGTAAGGAATGTGCCGGATGACGTGCATCGCGCTTTGCGCGTGCGGGCGGCCCAACATGGCCGCAG
TACGGAAGCGGAGGTGCGCGAGATTCTGGCGGCCGTGGTCAAGCCGGAGAAGCGCGTGCGTGTGGGTGAAGCCCTAGCCG
CCATCGGCCGCAAGATCGGGCTGACCAATGAGGATTTCGCCGTGTTCGAGAGCGTGCGCGACAAGACGCCGGCCAAACCG
TTGAGCTTCGAGTGA

Structures

Toxin

• AlphaFold DB: A0A837APC7

Antitoxin

• AlphaFold DB: A0A837APP1