Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2849826..2850661 Replicon chromosome
Accession NZ_CP028126
Organism Escherichia coli O26 str. RM10386

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag I3U_RS17210 Protein ID WP_000854757.1
Coordinates 2850284..2850661 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag I3U_RS17205 Protein ID WP_001295723.1
Coordinates 2849826..2850194 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3U_RS17160 2845935..2846282 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
I3U_RS17165 2846404..2846682 - 279 WP_001341328.1 transposase -
I3U_RS17170 2846771..2847112 + 342 WP_072097794.1 hypothetical protein -
I3U_RS17175 2847191..2847424 + 234 WP_001119729.1 DUF905 family protein -
I3U_RS17185 2847524..2848342 + 819 WP_001234620.1 DUF945 domain-containing protein -
I3U_RS17190 2848397..2848881 + 485 Protein_2939 antirestriction protein -
I3U_RS17195 2848897..2849373 + 477 WP_001186725.1 RadC family protein -
I3U_RS17200 2849442..2849663 + 222 WP_000692323.1 DUF987 domain-containing protein -
I3U_RS17205 2849826..2850194 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I3U_RS17210 2850284..2850661 + 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
I3U_RS17215 2850658..2850861 + 204 WP_000761705.1 hypothetical protein -
I3U_RS33380 2850874..2850987 + 114 WP_001161660.1 DUF957 domain-containing protein -
I3U_RS33385 2851803..2852174 + 372 WP_001295631.1 IS110 family transposase -
I3U_RS17235 2852628..2852810 + 183 WP_024167529.1 ethanolamine utilization protein -
I3U_RS17240 2852911..2853240 - 330 WP_000450409.1 DUF496 family protein -
I3U_RS17245 2853412..2854470 - 1059 WP_001200887.1 FUSC family protein -
I3U_RS17250 2854668..2855141 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T100651 WP_000854757.1 NZ_CP028126:2850284-2850661 [Escherichia coli O26 str. RM10386]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T100651 NZ_CP028126:2850284-2850661 [Escherichia coli O26 str. RM10386]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT100651 WP_001295723.1 NZ_CP028126:2849826-2850194 [Escherichia coli O26 str. RM10386]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT100651 NZ_CP028126:2849826-2850194 [Escherichia coli O26 str. RM10386]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGTGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References