Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/- |
| Location | 2699974..2700569 | Replicon | chromosome |
| Accession | NC_014500 | ||
| Organism | Dickeya dadantii 3937 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | E0SEA8 |
| Locus tag | DDA3937_RS11880 | Protein ID | WP_013318177.1 |
| Coordinates | 2699974..2700351 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | - |
| Locus tag | DDA3937_RS11885 | Protein ID | WP_033111896.1 |
| Coordinates | 2700348..2700569 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DDA3937_RS11860 (Dda3937_04144) | 2695588..2696478 | - | 891 | WP_033111895.1 | oxidoreductase | - |
| DDA3937_RS11865 (Dda3937_04603) | 2696610..2697233 | - | 624 | WP_013318174.1 | glutathione S-transferase | - |
| DDA3937_RS11870 (Dda3937_03801) | 2697586..2698464 | - | 879 | WP_013318175.1 | SIR2 family protein | - |
| DDA3937_RS11875 (Dda3937_04336) | 2698473..2699531 | - | 1059 | WP_013318176.1 | AAA family ATPase | - |
| DDA3937_RS11880 (Dda3937_03800) | 2699974..2700351 | - | 378 | WP_013318177.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| DDA3937_RS11885 (Dda3937_03799) | 2700348..2700569 | - | 222 | WP_033111896.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| DDA3937_RS11900 (Dda3937_03796) | 2702157..2703305 | - | 1149 | WP_013318179.1 | L-threonine dehydrogenase | - |
| DDA3937_RS11905 (Dda3937_03795) | 2703676..2704146 | + | 471 | WP_107768306.1 | NUDIX domain-containing protein | - |
| DDA3937_RS11910 (Dda3937_03794) | 2704218..2704895 | - | 678 | WP_013318181.1 | respiratory nitrate reductase subunit gamma | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2681764..2702068 | 20304 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14320.39 Da Isoelectric Point: 4.9309
>T10065 WP_013318177.1 NC_014500:c2700351-2699974 [Dickeya dadantii 3937]
MKWVSAQDVIDFHDRILQVLPGVVGMADPGRAEELIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGILIVDNDNSLEELTIKAATGECLVSELAEQLRQRVEK
MKWVSAQDVIDFHDRILQVLPGVVGMADPGRAEELIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGILIVDNDNSLEELTIKAATGECLVSELAEQLRQRVEK
Download Length: 378 bp
>T10065 NC_014500:c2700351-2699974 [Dickeya dadantii 3937]
ATGAAATGGGTGAGTGCGCAGGACGTCATTGACTTCCATGATCGTATTTTGCAGGTGTTGCCTGGTGTGGTGGGTATGGC
TGATCCGGGTCGGGCTGAGGAGTTGATTTATCGAGTACAAAACCGTCTTTATTATGAAGGTGTGACCGAACTGTTTGAGT
TGGCGGCGACGTATTGGGTAACTATTGCTCGTGGTCATATTTTTAATGATGGCAATAAACGCACTGCTTTTTTTGTTACC
ATGACATTTTTGCGTCGCAATGGCATATTGATTGTCGATAACGACAATTCGCTGGAAGAACTCACCATTAAGGCGGCAAC
CGGAGAATGCCTGGTGTCGGAACTCGCCGAACAATTAAGACAACGGGTGGAAAAATAA
ATGAAATGGGTGAGTGCGCAGGACGTCATTGACTTCCATGATCGTATTTTGCAGGTGTTGCCTGGTGTGGTGGGTATGGC
TGATCCGGGTCGGGCTGAGGAGTTGATTTATCGAGTACAAAACCGTCTTTATTATGAAGGTGTGACCGAACTGTTTGAGT
TGGCGGCGACGTATTGGGTAACTATTGCTCGTGGTCATATTTTTAATGATGGCAATAAACGCACTGCTTTTTTTGTTACC
ATGACATTTTTGCGTCGCAATGGCATATTGATTGTCGATAACGACAATTCGCTGGAAGAACTCACCATTAAGGCGGCAAC
CGGAGAATGCCTGGTGTCGGAACTCGCCGAACAATTAAGACAACGGGTGGAAAAATAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8179.32 Da Isoelectric Point: 7.2019
>AT10065 WP_033111896.1 NC_014500:c2700569-2700348 [Dickeya dadantii 3937]
MKTYTITEARQNIAAVIDTAASGEPVEIKRRDGTSAVLIPKAEFEAYQKAKLDTEFDFIMQRHGHTIKALADR
MKTYTITEARQNIAAVIDTAASGEPVEIKRRDGTSAVLIPKAEFEAYQKAKLDTEFDFIMQRHGHTIKALADR
Download Length: 222 bp
>AT10065 NC_014500:c2700569-2700348 [Dickeya dadantii 3937]
ATGAAGACTTATACCATTACTGAAGCCCGGCAAAACATTGCGGCGGTCATTGATACAGCAGCCAGCGGTGAGCCGGTAGA
GATTAAGCGTCGGGATGGCACTTCGGCTGTACTCATCCCCAAAGCAGAGTTTGAGGCTTATCAGAAAGCCAAATTAGACA
CTGAATTCGATTTCATCATGCAACGCCACGGACACACCATCAAAGCGCTCGCCGACAGATGA
ATGAAGACTTATACCATTACTGAAGCCCGGCAAAACATTGCGGCGGTCATTGATACAGCAGCCAGCGGTGAGCCGGTAGA
GATTAAGCGTCGGGATGGCACTTCGGCTGTACTCATCCCCAAAGCAGAGTTTGAGGCTTATCAGAAAGCCAAATTAGACA
CTGAATTCGATTTCATCATGCAACGCCACGGACACACCATCAAAGCGCTCGCCGACAGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Lidia Boss et al. (2021) Identification of Three Type II Toxin-Antitoxin Systems in Model Bacterial Plant Pathogen Dickeya dadantii 3937. International Journal of Molecular Sciences 22(11):5932. [PubMed:34073004]