Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2258990..2259516 | Replicon | chromosome |
| Accession | NZ_CP028126 | ||
| Organism | Escherichia coli O26 str. RM10386 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | I3U_RS13890 | Protein ID | WP_000323025.1 |
| Coordinates | 2258990..2259277 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | I3U_RS13895 | Protein ID | WP_000534858.1 |
| Coordinates | 2259277..2259516 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I3U_RS13850 | 2254014..2254229 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| I3U_RS33545 | 2254449..2254619 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| I3U_RS13855 | 2254983..2255198 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| I3U_RS13860 | 2255499..2255711 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| I3U_RS32980 | 2255766..2255855 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| I3U_RS13865 | 2256133..2256885 | - | 753 | WP_001047133.1 | antitermination protein | - |
| I3U_RS13870 | 2256899..2257948 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| I3U_RS13875 | 2257950..2258228 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| I3U_RS13880 | 2258295..2258546 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| I3U_RS13885 | 2258763..2258918 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| I3U_RS13890 | 2258990..2259277 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| I3U_RS13895 | 2259277..2259516 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| I3U_RS13900 | 2259541..2259846 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| I3U_RS13905 | 2260049..2260381 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| I3U_RS13910 | 2260818..2262158 | - | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| I3U_RS13915 | 2262192..2262611 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| I3U_RS13920 | 2262652..2263617 | - | 966 | WP_000054507.1 | hypothetical protein | - |
| I3U_RS13925 | 2263598..2264119 | - | 522 | WP_000705349.1 | hypothetical protein | - |
| I3U_RS13930 | 2264103..2264330 | - | 228 | WP_000476993.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleC | 2162004..2277549 | 115545 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T100641 WP_000323025.1 NZ_CP028126:c2259277-2258990 [Escherichia coli O26 str. RM10386]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T100641 NZ_CP028126:c2259277-2258990 [Escherichia coli O26 str. RM10386]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT100641 WP_000534858.1 NZ_CP028126:c2259516-2259277 [Escherichia coli O26 str. RM10386]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT100641 NZ_CP028126:c2259516-2259277 [Escherichia coli O26 str. RM10386]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|