Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1441364..1442159 Replicon chromosome
Accession NZ_CP028126
Organism Escherichia coli O26 str. RM10386

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag I3U_RS09015 Protein ID WP_000854914.1
Coordinates 1441785..1442159 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag I3U_RS09010 Protein ID WP_001280953.1
Coordinates 1441364..1441738 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3U_RS08970 1436719..1437624 + 906 WP_000203541.1 chemotaxis protein -
I3U_RS08975 1437621..1438691 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
I3U_RS08990 1439031..1439849 + 819 WP_001234682.1 DUF945 domain-containing protein -
I3U_RS08995 1439940..1440425 + 486 WP_000214398.1 antirestriction protein -
I3U_RS09000 1440441..1440917 + 477 WP_001186738.1 RadC family protein -
I3U_RS09005 1440980..1441201 + 222 WP_000692323.1 DUF987 domain-containing protein -
I3U_RS09010 1441364..1441738 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I3U_RS09015 1441785..1442159 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
I3U_RS09020 1442156..1442647 + 492 WP_000976857.1 hypothetical protein -
I3U_RS09025 1442659..1442856 + 198 WP_000839282.1 DUF957 domain-containing protein -
I3U_RS09030 1442941..1443783 + 843 WP_001280481.1 DUF4942 domain-containing protein -
I3U_RS09040 1444254..1445192 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
I3U_RS09045 1445247..1445984 + 738 WP_000283664.1 zinc-binding phosphatase -
I3U_RS09050 1446008..1446562 + 555 WP_001001902.1 molecular chaperone YcdY -
I3U_RS09055 1446664..1447155 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1429623..1452720 23097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T100632 WP_000854914.1 NZ_CP028126:1441785-1442159 [Escherichia coli O26 str. RM10386]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T100632 NZ_CP028126:1441785-1442159 [Escherichia coli O26 str. RM10386]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT100632 WP_001280953.1 NZ_CP028126:1441364-1441738 [Escherichia coli O26 str. RM10386]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT100632 NZ_CP028126:1441364-1441738 [Escherichia coli O26 str. RM10386]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References