Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1234430..1234908 Replicon chromosome
Accession NZ_CP028126
Organism Escherichia coli O26 str. RM10386

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag I3U_RS07600 Protein ID WP_001303876.1
Coordinates 1234430..1234717 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag I3U_RS07605 Protein ID WP_000536233.1
Coordinates 1234717..1234908 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3U_RS07565 1229653..1232103 - 2451 WP_000048583.1 exonuclease -
I3U_RS07570 1232197..1232388 - 192 WP_001098307.1 DUF1482 family protein -
I3U_RS07575 1232385..1232573 - 189 WP_000413705.1 cell division inhibition protein DicB -
I3U_RS07585 1233141..1233350 + 210 WP_001133037.1 hypothetical protein -
I3U_RS07590 1233351..1233989 - 639 WP_000394543.1 hypothetical protein -
I3U_RS07595 1234001..1234153 - 153 WP_000380316.1 DUF1391 family protein -
I3U_RS07600 1234430..1234717 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I3U_RS07605 1234717..1234908 - 192 WP_000536233.1 hypothetical protein Antitoxin
I3U_RS07610 1234936..1235337 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
I3U_RS07615 1235446..1235718 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
I3U_RS07620 1235702..1236127 + 426 WP_000693855.1 Rha family transcriptional regulator -
I3U_RS07625 1236334..1236789 - 456 WP_000273724.1 hypothetical protein -
I3U_RS07630 1236868..1237983 + 1116 WP_001205821.1 hypothetical protein -
I3U_RS07635 1237990..1238736 + 747 WP_000788742.1 ATP-binding protein -
I3U_RS07640 1238758..1239528 + 771 WP_096954161.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T100631 WP_001303876.1 NZ_CP028126:c1234717-1234430 [Escherichia coli O26 str. RM10386]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T100631 NZ_CP028126:c1234717-1234430 [Escherichia coli O26 str. RM10386]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT100631 WP_000536233.1 NZ_CP028126:c1234908-1234717 [Escherichia coli O26 str. RM10386]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT100631 NZ_CP028126:c1234908-1234717 [Escherichia coli O26 str. RM10386]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References