Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4722918..4723716 | Replicon | chromosome |
| Accession | NZ_CP028122 | ||
| Organism | Escherichia coli O43 str. RM10042 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1M0ZYM8 |
| Locus tag | I3W_RS25685 | Protein ID | WP_000854904.1 |
| Coordinates | 4722918..4723295 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A093DMQ4 |
| Locus tag | I3W_RS25690 | Protein ID | WP_001280952.1 |
| Coordinates | 4723342..4723716 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I3W_RS25660 | 4718949..4720486 | - | 1538 | Protein_4465 | lysine decarboxylation/transport transcriptional activator CadC | - |
| I3W_RS25670 | 4721297..4722139 | - | 843 | Protein_4466 | DUF4942 domain-containing protein | - |
| I3W_RS25675 | 4722224..4722421 | - | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| I3W_RS25680 | 4722433..4722921 | - | 489 | WP_000779174.1 | hypothetical protein | - |
| I3W_RS25685 | 4722918..4723295 | - | 378 | WP_000854904.1 | TA system toxin CbtA family protein | Toxin |
| I3W_RS25690 | 4723342..4723716 | - | 375 | WP_001280952.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| I3W_RS25695 | 4723879..4724100 | - | 222 | WP_000692311.1 | DUF987 domain-containing protein | - |
| I3W_RS25700 | 4724163..4724639 | - | 477 | WP_001186726.1 | RadC family protein | - |
| I3W_RS25705 | 4724655..4725140 | - | 486 | WP_000849591.1 | antirestriction protein | - |
| I3W_RS25710 | 4725195..4726013 | - | 819 | WP_001234620.1 | DUF945 domain-containing protein | - |
| I3W_RS25720 | 4726100..4726333 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| I3W_RS25725 | 4726412..4726867 | - | 456 | Protein_4476 | hypothetical protein | - |
| I3W_RS25730 | 4726943..4727377 | - | 435 | Protein_4477 | hypothetical protein | - |
| I3W_RS25735 | 4727388..4728293 | - | 906 | Protein_4478 | IS3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4711460..4745312 | 33852 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14280.26 Da Isoelectric Point: 7.2922
>T100624 WP_000854904.1 NZ_CP028122:c4723295-4722918 [Escherichia coli O43 str. RM10042]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T100624 NZ_CP028122:c4723295-4722918 [Escherichia coli O43 str. RM10042]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13719.50 Da Isoelectric Point: 6.6249
>AT100624 WP_001280952.1 NZ_CP028122:c4723716-4723342 [Escherichia coli O43 str. RM10042]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
Download Length: 375 bp
>AT100624 NZ_CP028122:c4723716-4723342 [Escherichia coli O43 str. RM10042]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0ZYM8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A093DMQ4 |