Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1794059..1794585 | Replicon | chromosome |
| Accession | NZ_CP028122 | ||
| Organism | Escherichia coli O43 str. RM10042 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | I3W_RS10490 | Protein ID | WP_000323025.1 |
| Coordinates | 1794059..1794346 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | I3W_RS10495 | Protein ID | WP_000534858.1 |
| Coordinates | 1794346..1794585 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I3W_RS10450 | 1789083..1789298 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| I3W_RS28030 | 1789518..1789688 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| I3W_RS10455 | 1790052..1790267 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| I3W_RS10460 | 1790568..1790780 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| I3W_RS27715 | 1790835..1790924 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| I3W_RS10465 | 1791202..1791954 | - | 753 | WP_001047135.1 | antitermination protein | - |
| I3W_RS10470 | 1791968..1793017 | - | 1050 | WP_108942346.1 | DUF968 domain-containing protein | - |
| I3W_RS10475 | 1793019..1793297 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| I3W_RS10480 | 1793364..1793615 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| I3W_RS10485 | 1793832..1793987 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| I3W_RS10490 | 1794059..1794346 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| I3W_RS10495 | 1794346..1794585 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| I3W_RS10500 | 1794610..1794915 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| I3W_RS10505 | 1795118..1795450 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| I3W_RS10515 | 1795887..1797200 | - | 1314 | WP_108942348.1 | ISNCY family transposase | - |
| I3W_RS27905 | 1797969..1798256 | - | 288 | Protein_1704 | hypothetical protein | - |
| I3W_RS10530 | 1798867..1799223 | - | 357 | WP_001310834.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1758289..1808909 | 50620 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T100607 WP_000323025.1 NZ_CP028122:c1794346-1794059 [Escherichia coli O43 str. RM10042]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T100607 NZ_CP028122:c1794346-1794059 [Escherichia coli O43 str. RM10042]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT100607 WP_000534858.1 NZ_CP028122:c1794585-1794346 [Escherichia coli O43 str. RM10042]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT100607 NZ_CP028122:c1794585-1794346 [Escherichia coli O43 str. RM10042]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|