Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 5444705..5445300 Replicon chromosome
Accession NZ_CP028116
Organism Escherichia coli O26 str. RM8426

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag I3M_RS30065 Protein ID WP_000239579.1
Coordinates 5444950..5445300 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag I3M_RS30060 Protein ID WP_001223208.1
Coordinates 5444705..5444956 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3M_RS30050 5440370..5444149 + 3780 WP_000060926.1 autotransporter assembly complex protein TamB -
I3M_RS30055 5444152..5444493 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
I3M_RS30060 5444705..5444956 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
I3M_RS30065 5444950..5445300 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
I3M_RS30070 5445380..5445910 - 531 WP_000055075.1 inorganic diphosphatase -
I3M_RS30075 5446220..5447176 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
I3M_RS30080 5447316..5448818 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
I3M_RS30085 5448832..5449854 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-114)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T100553 WP_000239579.1 NZ_CP028116:5444950-5445300 [Escherichia coli O26 str. RM8426]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T100553 NZ_CP028116:5444950-5445300 [Escherichia coli O26 str. RM8426]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT100553 WP_001223208.1 NZ_CP028116:5444705-5444956 [Escherichia coli O26 str. RM8426]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT100553 NZ_CP028116:5444705-5444956 [Escherichia coli O26 str. RM8426]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References