Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) darTG/-
Location 31528..34033 Replicon chromosome
Accession NZ_AJIP01000032
Organism Thermosipho africanus H17ap60334 Contig32

Toxin (Protein)


Gene name darT Uniprot ID K2PFJ6
Locus tag H17AP60334_RS06860 Protein ID WP_004103096.1
Coordinates 31528..32694 (+) Length 389 a.a.

Antitoxin (Protein)


Gene name darG Uniprot ID K2PBX9
Locus tag H17AP60334_RS06875 Protein ID WP_004103098.1
Coordinates 33497..34033 (+) Length 179 a.a.

Genomic Context

H17AP60334_RS06845H17AP60334_RS06855H17AP60334_RS06860H17AP60334_RS12490H17AP60334_RS06870H17AP60334_RS06875H17AP60334_RS06880H17AP60334_RS11155H17AP60334_RS06885H17AP60334_RS06890H17AP60334_RS06895H17AP60334_RS06850H17AP60334_RS06900
Location: 27044..28447 (1404 bp)
Type: Others
Protein ID: WP_004103090.1
Location: 29929..30495 (567 bp)
Type: Others
Protein ID: WP_004103094.1
Location: 31528..32694 (1167 bp)
Type: Toxin
Protein ID: WP_004103096.1
Location: 32762..32998 (237 bp)
Type: Others
Protein ID: WP_038042555.1
Location: 32995..33483 (489 bp)
Type: Others
Protein ID: WP_038042557.1
Location: 33497..34033 (537 bp)
Type: Antitoxin
Protein ID: WP_004103098.1
Location: 34041..34409 (369 bp)
Type: Others
Protein ID: WP_004103100.1
Location: 34716..34871 (156 bp)
Type: Others
Protein ID: WP_004103102.1
Location: 35530..36192 (663 bp)
Type: Others
Protein ID: WP_198429593.1
Location: 36580..37035 (456 bp)
Type: Others
Protein ID: WP_004103107.1
Location: 37227..37805 (579 bp)
Type: Others
Protein ID: WP_232617955.1
Location: 28527..29735 (1209 bp)
Type: Others
Protein ID: WP_004103092.1
Location: 37958..38886 (929 bp)
Type: Others
Protein ID: Protein_44
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H17AP60334_RS06845 (H17ap60334_07398)27044..28447+1404WP_004103090.1dipeptidase PepV-
H17AP60334_RS06850 (H17ap60334_07403)28527..29735-1209WP_004103092.1MFS transporter-
H17AP60334_RS06855 (H17ap60334_07408)29929..30495+567WP_004103094.1DUF2202 domain-containing protein-
H17AP60334_RS06860 (H17ap60334_07413)31528..32694+1167WP_004103096.1DarT ssDNA thymidine ADP-ribosyltransferase family proteinToxin
H17AP60334_RS1249032762..32998+237WP_038042555.1TIGR04255 family protein-
H17AP60334_RS0687032995..33483+489WP_038042557.1TIGR04255 family protein-
H17AP60334_RS06875 (H17ap60334_07428)33497..34033+537WP_004103098.1hypothetical proteinAntitoxin
H17AP60334_RS06880 (H17ap60334_07433)34041..34409+369WP_004103100.1HEPN domain-containing protein-
H17AP60334_RS11155 (H17ap60334_07438)34716..34871+156WP_004103102.1DUF2202 domain-containing protein-
H17AP60334_RS06885 (H17ap60334_07443)35530..36192+663WP_198429593.1hypothetical protein-
H17AP60334_RS06890 (H17ap60334_07448)36580..37035+456WP_004103107.1hypothetical protein-
H17AP60334_RS0689537227..37805+579WP_232617955.1sulfite exporter TauE/SafE family protein-
H17AP60334_RS0690037958..38886-929Protein_44alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Macro domain

(227-350)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 389 a.a.        Molecular weight: 44883.37 Da        Isoelectric Point: 9.4675

>T10055 WP_004103096.1 NZ_AJIP01000032:31528-32694 [Thermosipho africanus H17ap60334]
MFPRFRELYYITHIDNVPSILEKGILSHAEIERQSINCKKVYDNSIVLKRKSRLLADNRSLWEFANLYFQPRNPMLYRLL
VQGLKPKDLAIVAVKWTIMKRDDILITDGNAASSETQIYRKSEIKNIKNIISVKDMEYWREEDGSKRKIMAECLVPQCVD
PRYISAIYVSDHEVASNLKKAINNRNIPVIPDPTFFFLPNREIKLTQNLSLVEGDMFFSRMQTLTVSVNTVGVMGKGLAS
RVKYQFPDVYVVFQDACKKKELEFGKPYLYKRESSLDAFLAEDGEKLSDLNHQTWFLLFPTKRHWKNMSEIKGIESGLRW
IVENYKKEGIKSLAVPALGCGLGGLEWSIVGPLMCRYLTKLEIPVQIYLPLEKRIPDVQLSPKFLLDS

Download         Length: 1167 bp

>T10055 NZ_AJIP01000032:31528-32694 [Thermosipho africanus H17ap60334]
ATGTTCCCGAGATTTAGGGAACTTTATTATATAACACATATTGATAATGTGCCTTCTATTTTAGAAAAAGGAATTTTATC
CCACGCGGAAATTGAAAGGCAATCTATAAATTGCAAGAAGGTATACGACAATAGTATTGTATTAAAAAGAAAAAGTAGAT
TATTGGCTGATAACAGATCCCTTTGGGAATTTGCTAATTTGTACTTCCAACCAAGAAATCCTATGCTTTATCGCTTATTG
GTGCAAGGGCTAAAACCAAAAGATCTTGCGATAGTAGCTGTAAAATGGACAATAATGAAGAGGGATGATATATTAATTAC
TGATGGTAATGCTGCCTCGAGTGAGACGCAGATATACCGAAAAAGTGAGATAAAAAATATCAAAAATATTATTTCAGTTA
AGGATATGGAATATTGGCGCGAAGAAGATGGTTCGAAAAGAAAGATAATGGCTGAATGTTTGGTACCTCAGTGTGTTGAT
CCTAGATATATTAGTGCAATATATGTTAGTGACCACGAAGTAGCAAGCAATTTGAAAAAAGCAATAAACAACAGAAATAT
ACCTGTTATACCAGATCCTACTTTTTTCTTCTTACCAAATAGAGAGATTAAACTGACCCAGAATTTATCACTTGTTGAAG
GTGATATGTTCTTCTCAAGGATGCAAACATTAACAGTTAGTGTTAATACAGTTGGTGTAATGGGCAAAGGACTTGCTTCA
CGAGTGAAGTATCAATTTCCAGATGTTTATGTTGTTTTTCAAGACGCTTGCAAAAAGAAAGAACTTGAATTTGGTAAGCC
TTATTTGTACAAAAGGGAATCATCACTGGATGCATTTCTCGCTGAGGATGGCGAAAAGTTATCGGATCTCAATCACCAGA
CATGGTTTTTATTATTTCCTACTAAACGCCACTGGAAAAATATGTCAGAAATTAAAGGCATAGAATCTGGATTGCGTTGG
ATTGTTGAAAATTACAAAAAGGAAGGAATAAAATCCTTAGCGGTCCCTGCACTTGGTTGTGGACTTGGTGGTTTGGAATG
GTCAATTGTGGGGCCGTTAATGTGTAGATATTTGACTAAGCTTGAAATACCTGTACAAATTTATTTACCACTTGAAAAGC
GGATTCCGGATGTGCAATTATCACCGAAATTTTTGCTGGATAGTTGA

Antitoxin


Download         Length: 179 a.a.        Molecular weight: 21099.24 Da        Isoelectric Point: 7.0200

>AT10055 WP_004103098.1 NZ_AJIP01000032:33497-34033 [Thermosipho africanus H17ap60334]
MENNVIRTPLLENQLFNFPEEKSKTSEARKGIKIASRSLPFYDSSTYMQSFQRQIWPSSTKSTLTDKIYSFISNVIQMGV
HVEEDKKVSNYLLNFPDMQWVINIAIEVVKRYLPGVKLFLDLYQDPEIEDKFLVLYVRTTNYNRDFIEKLRKAEEEVIKL
LVDKQGWIQITSDFREVR

Download         Length: 537 bp

>AT10055 NZ_AJIP01000032:33497-34033 [Thermosipho africanus H17ap60334]
ATGGAGAATAATGTAATTAGAACACCACTTTTAGAAAACCAATTATTTAATTTTCCTGAGGAAAAATCTAAAACTTCTGA
AGCGAGAAAAGGAATTAAAATAGCGTCGAGGAGTTTACCTTTTTATGACTCATCTACTTACATGCAAAGCTTCCAGAGAC
AAATATGGCCTTCGAGTACAAAATCAACTTTAACTGATAAAATATACAGTTTTATAAGCAACGTTATTCAAATGGGAGTT
CATGTTGAGGAAGATAAAAAAGTTAGCAATTATCTTTTAAATTTTCCAGATATGCAATGGGTTATTAATATAGCAATTGA
AGTAGTTAAACGTTATTTACCAGGAGTAAAGTTATTTTTGGATCTCTATCAAGATCCGGAAATAGAAGATAAGTTTCTCG
TGTTGTATGTTAGAACTACAAATTATAATAGAGATTTCATAGAAAAGTTGAGGAAGGCAGAAGAAGAAGTTATAAAATTA
CTTGTTGATAAGCAAGGTTGGATACAGATTACTAGTGACTTTCGTGAAGTGAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7OMU

Antitoxin

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Source
ID
Structure
AlphaFold DBK2PBX9

References

(1) Marion Schuller et al. (2021) Molecular basis for DarT ADP-ribosylation of a DNA base. Nature 596(7873):597-602. [PubMed:34408320] 3D_structure


3D_structure protein structure literature