Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2797220..2798055 Replicon chromosome
Accession NZ_CP028116
Organism Escherichia coli O26 str. RM8426

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag I3M_RS16285 Protein ID WP_000854757.1
Coordinates 2797678..2798055 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag I3M_RS16280 Protein ID WP_001295723.1
Coordinates 2797220..2797588 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3M_RS16235 2793327..2793674 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
I3M_RS16240 2793671..2794075 - 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
I3M_RS16245 2794164..2794505 + 342 WP_072097794.1 hypothetical protein -
I3M_RS16250 2794584..2794817 + 234 WP_001119729.1 DUF905 family protein -
I3M_RS16260 2794917..2795735 + 819 WP_001234620.1 DUF945 domain-containing protein -
I3M_RS16265 2795790..2796275 + 486 WP_000849582.1 antirestriction protein -
I3M_RS16270 2796291..2796767 + 477 WP_001186725.1 RadC family protein -
I3M_RS16275 2796836..2797057 + 222 WP_000692323.1 DUF987 domain-containing protein -
I3M_RS16280 2797220..2797588 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I3M_RS16285 2797678..2798055 + 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
I3M_RS16290 2798052..2798255 + 204 WP_000761705.1 hypothetical protein -
I3M_RS16295 2798268..2798381 + 114 WP_001161660.1 DUF957 domain-containing protein -
I3M_RS31835 2799197..2799568 + 372 WP_001295631.1 IS110 family transposase -
I3M_RS16310 2800022..2800204 + 183 WP_024167529.1 ethanolamine utilization protein -
I3M_RS16315 2800305..2800634 - 330 WP_000450409.1 DUF496 family protein -
I3M_RS16320 2800806..2801864 - 1059 WP_001200887.1 FUSC family protein -
I3M_RS16325 2802062..2802535 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T100544 WP_000854757.1 NZ_CP028116:2797678-2798055 [Escherichia coli O26 str. RM8426]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T100544 NZ_CP028116:2797678-2798055 [Escherichia coli O26 str. RM8426]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT100544 WP_001295723.1 NZ_CP028116:2797220-2797588 [Escherichia coli O26 str. RM8426]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT100544 NZ_CP028116:2797220-2797588 [Escherichia coli O26 str. RM8426]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References