Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2579306..2579777 Replicon chromosome
Accession NZ_CP028116
Organism Escherichia coli O26 str. RM8426

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A1Y2Y8G6
Locus tag I3M_RS15140 Protein ID WP_001448501.1
Coordinates 2579499..2579777 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag I3M_RS15135 Protein ID WP_001302048.1
Coordinates 2579306..2579497 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3M_RS15085 2574385..2574603 - 219 WP_000683609.1 DUF4014 family protein -
I3M_RS15090 2574731..2575042 - 312 WP_001289673.1 hypothetical protein -
I3M_RS15095 2575035..2575262 - 228 WP_000699809.1 hypothetical protein -
I3M_RS15100 2575259..2575540 - 282 WP_000603384.1 DNA-binding protein -
I3M_RS15105 2575573..2576333 - 761 Protein_2661 DUF1627 domain-containing protein -
I3M_RS15110 2576359..2577100 - 742 Protein_2662 ATP-binding protein -
I3M_RS15115 2577107..2578069 - 963 WP_001444941.1 helix-turn-helix domain-containing protein -
I3M_RS15120 2578092..2578517 - 426 WP_000693943.1 Rha family transcriptional regulator -
I3M_RS15125 2578514..2578816 - 303 WP_000172738.1 transcriptional regulator -
I3M_RS15130 2578914..2579285 + 372 WP_001169687.1 hypothetical protein -
I3M_RS15135 2579306..2579497 + 192 WP_001302048.1 hypothetical protein Antitoxin
I3M_RS15140 2579499..2579777 + 279 WP_001448501.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I3M_RS15145 2580064..2580216 + 153 WP_001427316.1 DUF1391 family protein -
I3M_RS15150 2580637..2580858 + 222 WP_000560218.1 killing protein KilR -
I3M_RS15155 2580852..2581028 + 177 WP_000245534.1 hypothetical protein -
I3M_RS15160 2581102..2581377 + 276 WP_001307773.1 hypothetical protein -
I3M_RS15165 2581476..2584127 + 2652 WP_000105101.1 exodeoxyribonuclease VIII -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleG7' 2531964..2592654 60690


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10691.27 Da        Isoelectric Point: 5.5647

>T100535 WP_001448501.1 NZ_CP028116:2579499-2579777 [Escherichia coli O26 str. RM8426]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPSLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T100535 NZ_CP028116:2579499-2579777 [Escherichia coli O26 str. RM8426]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTAGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT100535 WP_001302048.1 NZ_CP028116:2579306-2579497 [Escherichia coli O26 str. RM8426]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT100535 NZ_CP028116:2579306-2579497 [Escherichia coli O26 str. RM8426]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y2Y8G6

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References