Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2159759..2160285 | Replicon | chromosome |
| Accession | NZ_CP028116 | ||
| Organism | Escherichia coli O26 str. RM8426 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | I3M_RS12610 | Protein ID | WP_000323025.1 |
| Coordinates | 2159759..2160046 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | I3M_RS12615 | Protein ID | WP_000534858.1 |
| Coordinates | 2160046..2160285 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I3M_RS12570 | 2154783..2154998 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| I3M_RS31965 | 2155218..2155388 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| I3M_RS12575 | 2155752..2155967 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| I3M_RS12580 | 2156268..2156480 | + | 213 | WP_106875218.1 | cold shock-like protein CspF | - |
| I3M_RS31480 | 2156535..2156624 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| I3M_RS12585 | 2156902..2157654 | - | 753 | WP_001047133.1 | antitermination protein | - |
| I3M_RS12590 | 2157668..2158717 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| I3M_RS12595 | 2158719..2158997 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| I3M_RS12600 | 2159064..2159315 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| I3M_RS12605 | 2159532..2159687 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| I3M_RS12610 | 2159759..2160046 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| I3M_RS12615 | 2160046..2160285 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| I3M_RS12620 | 2160310..2160615 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| I3M_RS12625 | 2160818..2161150 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| I3M_RS12630 | 2161587..2162927 | - | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| I3M_RS12635 | 2162961..2163380 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| I3M_RS12640 | 2163421..2164386 | - | 966 | WP_000054507.1 | hypothetical protein | - |
| I3M_RS12645 | 2164367..2164888 | - | 522 | WP_000705349.1 | hypothetical protein | - |
| I3M_RS12650 | 2164872..2165099 | - | 228 | WP_000476993.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleC | 2124433..2227168 | 102735 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T100534 WP_000323025.1 NZ_CP028116:c2160046-2159759 [Escherichia coli O26 str. RM8426]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T100534 NZ_CP028116:c2160046-2159759 [Escherichia coli O26 str. RM8426]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT100534 WP_000534858.1 NZ_CP028116:c2160285-2160046 [Escherichia coli O26 str. RM8426]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT100534 NZ_CP028116:c2160285-2160046 [Escherichia coli O26 str. RM8426]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|