Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 28388..29031 Replicon plasmid pRM8352
Accession NZ_CP028111
Organism Escherichia coli O121 str. RM8352

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag I3S_RS28810 Protein ID WP_001044768.1
Coordinates 28615..29031 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag I3S_RS28805 Protein ID WP_001261287.1
Coordinates 28388..28618 (+) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3S_RS28760 24253..25692 + 1440 WP_001213545.1 enterohemolysin T1SS ABC transporter subunit EhxD -
I3S_RS28765 25759..25902 + 144 Protein_20 transcriptional regulator -
I3S_RS28770 25906..26097 + 192 Protein_21 lipid II-degrading bacteriocin -
I3S_RS28775 26105..26458 - 354 WP_000864810.1 colicin M immunity protein -
I3S_RS28780 26631..27413 - 783 WP_001164205.1 site-specific integrase -
I3S_RS28785 27415..27828 - 414 WP_000465041.1 hypothetical protein -
I3S_RS28805 28388..28618 + 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I3S_RS28810 28615..29031 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
I3S_RS28825 29534..30746 - 1213 Protein_27 IS3 family transposase -
I3S_RS28830 30802..33051 - 2250 Protein_28 hypothetical protein -
I3S_RS28835 33069..33452 - 384 WP_101329730.1 hydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hlyC / hlyA / hlyB / hlyD / espP / toxB 1..83211 83211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-129)

Antitoxin

(7-52)


Sequences


Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T100486 WP_001044768.1 NZ_CP028111:28615-29031 [Escherichia coli O121 str. RM8352]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T100486 NZ_CP028111:28615-29031 [Escherichia coli O121 str. RM8352]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGCATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGGGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT100486 WP_001261287.1 NZ_CP028111:28388-28618 [Escherichia coli O121 str. RM8352]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT100486 NZ_CP028111:28388-28618 [Escherichia coli O121 str. RM8352]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A606Q844


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References