Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | AAA-ATPase/subtilisin-like serine protease/- |
| Location | 175482..178809 | Replicon | chromosome |
| Accession | NZ_CP001668 | ||
| Organism | Mycoplasma mycoides subsp. capri str. GM12 | ||
Toxin (Protein)
| Gene name | subtilisin-likeserineprotease | Uniprot ID | A0A7Z7PM44 |
| Locus tag | MMCAP2_RS00685 | Protein ID | WP_020862525.1 |
| Coordinates | 176536..178809 (+) | Length | 758 a.a. |
Antitoxin (Protein)
| Gene name | AAA-ATPase | Uniprot ID | A0A7Z7LB51 |
| Locus tag | MMCAP2_RS00680 | Protein ID | WP_020862524.1 |
| Coordinates | 175482..176543 (+) | Length | 354 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MMCAP2_RS00660 (MMCAP2_0128) | 171058..171486 | + | 429 | WP_017698046.1 | DNA-directed RNA polymerase subunit delta | - |
| MMCAP2_RS00665 (MMCAP2_0129) | 171578..173176 | + | 1599 | WP_020862522.1 | CTP synthase | - |
| MMCAP2_RS00670 (MMCAP2_0130) | 173307..174281 | + | 975 | WP_020862523.1 | DUF285 domain-containing protein | - |
| MMCAP2_RS00675 (MMCAP2_0131) | 174440..175333 | + | 894 | WP_011166343.1 | class II fructose-1,6-bisphosphate aldolase | - |
| MMCAP2_RS00680 (MMCAP2_0132) | 175482..176543 | + | 1062 | WP_020862524.1 | ATP-binding protein | Antitoxin |
| MMCAP2_RS00685 (MMCAP2_0133) | 176536..178809 | + | 2274 | WP_020862525.1 | S8 family peptidase | Toxin |
| MMCAP2_RS00690 (MMCAP2_0134) | 178915..180402 | - | 1488 | WP_020862526.1 | MFS transporter | - |
| MMCAP2_RS00695 (MMCAP2_0136) | 180998..181702 | + | 705 | WP_020862528.1 | glycerophosphodiester phosphodiesterase | - |
| MMCAP2_RS00700 (MMCAP2_0137) | 181862..182140 | + | 279 | WP_020862529.1 | 50S ribosomal protein L31 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 758 a.a. Molecular weight: 85629.10 Da Isoelectric Point: 9.3493
>T10046 WP_020862525.1 NZ_CP001668:176536-178809 [Mycoplasma mycoides subsp. capri str. GM12]
MNNLIVLKGKFEPGKNTKKPNSPQIPKTSIIKLEDCYRILDQLIKASSFKEQKIDINPIINVKYKRIISKSNRVSYLLLK
SLQKNNEHIIGSSFLDELVEKKIVKKQVITYCLTQKDLQEAIKRLDTITNILKKTHFKRIDNNLINLIANEQYLPIKKEI
QKYEFLSRTAFISTLVDLNYIEEIFIKTTHIDNNVDSVVTLYDTGIKAIDLLNKLDINVNMSDFIDDYTLFLDRNQYNEL
KTKAPFLISMSVDDLTKFIIDDKQEEITKNDIISIPDPTNEPIVGVIDTMFCKDVYFSKVDFRKEVSDDILLDSKDYQHG
TQVSSIIVDGPSFNKKLEDGCGRFRVRHFGVMAHSSGNVFSLFKKIKSIVINNLDIKVNLSLGSIREVSSNYISLLGSLL
DQLQYENDVIFIVAGTNDNECKQKIVGSPADSINSIVVNSVDFKNKPANYSRKGPVLTYFNKPDISYYGGVDNNKITVCG
CYGEAKVQGTSFAAPITRKVAYLIYKMNYSKEEAKALIIDSAIKFDKQKDNNRDLIGYGVVPIHINEILQSKNTDIKVLL
SYNTKAYYTYNFNLPVPTKENKFPFIAKLTFAYFAESQRSQGVDYTQDELDIQFGPIDNKSESINDINENNQSSSSSNAY
IYEYEARKMFAKNTVKSIIKSKTNKGKKRQFIKTTNNRGIRVIRKTRTDNINNKSIKFSLVITFRSIDNKDRIEEFISLC
NKSGYVASKVQIDNKIDIHGKSNEYLDFE
MNNLIVLKGKFEPGKNTKKPNSPQIPKTSIIKLEDCYRILDQLIKASSFKEQKIDINPIINVKYKRIISKSNRVSYLLLK
SLQKNNEHIIGSSFLDELVEKKIVKKQVITYCLTQKDLQEAIKRLDTITNILKKTHFKRIDNNLINLIANEQYLPIKKEI
QKYEFLSRTAFISTLVDLNYIEEIFIKTTHIDNNVDSVVTLYDTGIKAIDLLNKLDINVNMSDFIDDYTLFLDRNQYNEL
KTKAPFLISMSVDDLTKFIIDDKQEEITKNDIISIPDPTNEPIVGVIDTMFCKDVYFSKVDFRKEVSDDILLDSKDYQHG
TQVSSIIVDGPSFNKKLEDGCGRFRVRHFGVMAHSSGNVFSLFKKIKSIVINNLDIKVNLSLGSIREVSSNYISLLGSLL
DQLQYENDVIFIVAGTNDNECKQKIVGSPADSINSIVVNSVDFKNKPANYSRKGPVLTYFNKPDISYYGGVDNNKITVCG
CYGEAKVQGTSFAAPITRKVAYLIYKMNYSKEEAKALIIDSAIKFDKQKDNNRDLIGYGVVPIHINEILQSKNTDIKVLL
SYNTKAYYTYNFNLPVPTKENKFPFIAKLTFAYFAESQRSQGVDYTQDELDIQFGPIDNKSESINDINENNQSSSSSNAY
IYEYEARKMFAKNTVKSIIKSKTNKGKKRQFIKTTNNRGIRVIRKTRTDNINNKSIKFSLVITFRSIDNKDRIEEFISLC
NKSGYVASKVQIDNKIDIHGKSNEYLDFE
Download Length: 2274 bp
>T10046 NZ_CP001668:176536-178809 [Mycoplasma mycoides subsp. capri str. GM12]
ATGAATAATCTAATTGTATTAAAAGGAAAGTTTGAACCAGGTAAAAATACTAAGAAACCTAATAGTCCTCAAATACCAAA
AACATCTATTATAAAATTAGAAGATTGTTATAGAATTCTTGATCAATTAATAAAAGCATCTAGTTTTTGAAAAGAACAAA
AAATAGATATTAATCCAATAATAAATGTTAAATATAAAAGAATTATTTCTAAAAGTAACAGAGTAAGTTATTTGTTGTTA
AAAAGTTTACAAAAAAATAACGAGCATATTATAGGTTCAAGTTTTTTGGATGAATTAGTTGAAAAAAAAATAGTGAAAAA
GCAAGTCATCACTTATTGTCTGACACAAAAAGATTTACAAGAAGCAATAAAAAGATTAGATACAATAACTAATATTTTAA
AAAAAACTCATTTTAAACGAATTGATAATAACTTAATTAACCTAATAGCTAATGAACAATATTTACCTATAAAAAAAGAA
ATTCAAAAATATGAATTTCTTAGTAGAACAGCTTTTATATCAACTTTGGTTGACCTTAATTACATAGAAGAAATTTTTAT
AAAAACTACTCATATTGATAATAATGTTGATAGTGTAGTCACTTTATATGATACAGGTATAAAAGCAATTGATTTGTTAA
ATAAACTTGATATTAATGTTAATATGTCAGATTTTATTGATGATTACACCTTATTTTTAGATAGAAATCAGTATAATGAA
TTAAAAACTAAGGCACCGTTTTTAATATCTATGTCAGTTGATGATCTTACTAAATTCATAATAGATGATAAACAAGAAGA
AATTACAAAAAATGATATTATTTCTATACCAGATCCAACTAATGAACCAATAGTTGGCGTTATTGATACAATGTTTTGTA
AAGATGTTTATTTTTCTAAATGAGTAGATTTTAGAAAAGAGGTTTCTGATGATATTTTATTAGATTCTAAAGATTATCAA
CATGGAACTCAAGTTAGTTCTATTATTGTTGATGGTCCTTCTTTTAATAAAAAATTAGAAGATGGATGTGGAAGGTTTAG
AGTTAGACATTTTGGTGTTATGGCACATTCTAGTGGCAATGTCTTTTCTTTATTTAAAAAAATAAAATCGATAGTTATTA
ATAACTTAGATATAAAAGTTTGAAATTTATCATTAGGTTCAATTCGTGAAGTTAGTTCTAATTATATCTCATTACTAGGT
TCTTTACTTGATCAATTACAATATGAAAATGACGTTATTTTTATTGTTGCAGGAACTAATGATAACGAGTGTAAACAAAA
AATAGTAGGTTCACCTGCTGATTCAATAAACTCAATTGTTGTTAATTCAGTAGATTTTAAAAATAAACCAGCAAATTACT
CTCGTAAAGGTCCTGTTTTAACATATTTTAATAAACCTGATATTAGTTATTATGGTGGAGTTGATAATAATAAAATTACT
GTATGTGGCTGTTATGGTGAAGCAAAAGTTCAAGGTACTTCATTTGCAGCCCCATGAATTACTAGAAAAGTAGCTTATTT
AATTTATAAAATGAATTATAGTAAAGAAGAAGCAAAAGCGTTAATAATTGATTCAGCAATTAAATTTGATAAACAAAAAG
ATAATAATAGAGATCTTATTGGATATGGTGTAGTTCCTATACATATTAATGAAATACTACAATCAAAAAATACTGATATA
AAAGTTTTATTATCATATAATACAAAAGCTTATTATACATATAATTTCAACTTACCAGTTCCAACTAAAGAAAATAAATT
TCCCTTTATTGCAAAACTTACTTTTGCTTATTTTGCAGAATCACAAAGAAGTCAAGGTGTTGACTATACACAAGATGAAT
TAGATATTCAATTTGGACCAATAGATAACAAATCTGAATCTATTAATGATATAAATGAAAATAATCAATCTAGTTCTAGT
TCAAATGCTTATATTTATGAATATGAAGCTAGAAAAATGTTTGCAAAATGAAATACTGTTAAATCTATAATCAAATGATC
TAAAACTAATAAAGGTAAAAAAAGACAATTTATAAAAACAACAAATAACAGATGAGGTATTAGAGTAATTAGAAAAACTA
GAACTGATAATATAAATAATAAATCAATAAAGTTTAGTCTAGTTATAACTTTTAGATCCATTGATAATAAAGATAGAATT
GAAGAGTTTATTAGTTTGTGTAACAAAAGTGGTTATTGAGTTGCAAGTAAAGTTCAAATTGATAATAAAATTGATATTCA
TGGAAAGTCAAATGAATATTTAGATTTTGAATAG
ATGAATAATCTAATTGTATTAAAAGGAAAGTTTGAACCAGGTAAAAATACTAAGAAACCTAATAGTCCTCAAATACCAAA
AACATCTATTATAAAATTAGAAGATTGTTATAGAATTCTTGATCAATTAATAAAAGCATCTAGTTTTTGAAAAGAACAAA
AAATAGATATTAATCCAATAATAAATGTTAAATATAAAAGAATTATTTCTAAAAGTAACAGAGTAAGTTATTTGTTGTTA
AAAAGTTTACAAAAAAATAACGAGCATATTATAGGTTCAAGTTTTTTGGATGAATTAGTTGAAAAAAAAATAGTGAAAAA
GCAAGTCATCACTTATTGTCTGACACAAAAAGATTTACAAGAAGCAATAAAAAGATTAGATACAATAACTAATATTTTAA
AAAAAACTCATTTTAAACGAATTGATAATAACTTAATTAACCTAATAGCTAATGAACAATATTTACCTATAAAAAAAGAA
ATTCAAAAATATGAATTTCTTAGTAGAACAGCTTTTATATCAACTTTGGTTGACCTTAATTACATAGAAGAAATTTTTAT
AAAAACTACTCATATTGATAATAATGTTGATAGTGTAGTCACTTTATATGATACAGGTATAAAAGCAATTGATTTGTTAA
ATAAACTTGATATTAATGTTAATATGTCAGATTTTATTGATGATTACACCTTATTTTTAGATAGAAATCAGTATAATGAA
TTAAAAACTAAGGCACCGTTTTTAATATCTATGTCAGTTGATGATCTTACTAAATTCATAATAGATGATAAACAAGAAGA
AATTACAAAAAATGATATTATTTCTATACCAGATCCAACTAATGAACCAATAGTTGGCGTTATTGATACAATGTTTTGTA
AAGATGTTTATTTTTCTAAATGAGTAGATTTTAGAAAAGAGGTTTCTGATGATATTTTATTAGATTCTAAAGATTATCAA
CATGGAACTCAAGTTAGTTCTATTATTGTTGATGGTCCTTCTTTTAATAAAAAATTAGAAGATGGATGTGGAAGGTTTAG
AGTTAGACATTTTGGTGTTATGGCACATTCTAGTGGCAATGTCTTTTCTTTATTTAAAAAAATAAAATCGATAGTTATTA
ATAACTTAGATATAAAAGTTTGAAATTTATCATTAGGTTCAATTCGTGAAGTTAGTTCTAATTATATCTCATTACTAGGT
TCTTTACTTGATCAATTACAATATGAAAATGACGTTATTTTTATTGTTGCAGGAACTAATGATAACGAGTGTAAACAAAA
AATAGTAGGTTCACCTGCTGATTCAATAAACTCAATTGTTGTTAATTCAGTAGATTTTAAAAATAAACCAGCAAATTACT
CTCGTAAAGGTCCTGTTTTAACATATTTTAATAAACCTGATATTAGTTATTATGGTGGAGTTGATAATAATAAAATTACT
GTATGTGGCTGTTATGGTGAAGCAAAAGTTCAAGGTACTTCATTTGCAGCCCCATGAATTACTAGAAAAGTAGCTTATTT
AATTTATAAAATGAATTATAGTAAAGAAGAAGCAAAAGCGTTAATAATTGATTCAGCAATTAAATTTGATAAACAAAAAG
ATAATAATAGAGATCTTATTGGATATGGTGTAGTTCCTATACATATTAATGAAATACTACAATCAAAAAATACTGATATA
AAAGTTTTATTATCATATAATACAAAAGCTTATTATACATATAATTTCAACTTACCAGTTCCAACTAAAGAAAATAAATT
TCCCTTTATTGCAAAACTTACTTTTGCTTATTTTGCAGAATCACAAAGAAGTCAAGGTGTTGACTATACACAAGATGAAT
TAGATATTCAATTTGGACCAATAGATAACAAATCTGAATCTATTAATGATATAAATGAAAATAATCAATCTAGTTCTAGT
TCAAATGCTTATATTTATGAATATGAAGCTAGAAAAATGTTTGCAAAATGAAATACTGTTAAATCTATAATCAAATGATC
TAAAACTAATAAAGGTAAAAAAAGACAATTTATAAAAACAACAAATAACAGATGAGGTATTAGAGTAATTAGAAAAACTA
GAACTGATAATATAAATAATAAATCAATAAAGTTTAGTCTAGTTATAACTTTTAGATCCATTGATAATAAAGATAGAATT
GAAGAGTTTATTAGTTTGTGTAACAAAAGTGGTTATTGAGTTGCAAGTAAAGTTCAAATTGATAATAAAATTGATATTCA
TGGAAAGTCAAATGAATATTTAGATTTTGAATAG
Antitoxin
Download Length: 354 a.a. Molecular weight: 41351.78 Da Isoelectric Point: 7.4134
>AT10046 WP_020862524.1 NZ_CP001668:175482-176543 [Mycoplasma mycoides subsp. capri str. GM12]
MKKANVLNLIRYHIEENDISFRKEARIIAEEFYKMGDDELAEYVLFMLRDANHFVPQIDQEYDIQIPFTQKIELERNSEP
LPLPQVISEEIKGVINAISKNRKINKFLFQGFPGTGKTETVKQIARILNRNLFMVDFNNLIDSHLGQSSKNIAELFQKIN
QTPNPKKIIICFDEIDALALDRTNKTDLREMGRVTTAVFQGLDKLDTDIIVFATTNLFKHFDKALIRRFDLVIDFNRYTK
KDMLDIAEIILKHYIKKVDNIKSELRLFRKIISLSEELIYPGDLKNIIKSSIYLSDYEDQYDYLKRIYKKITDDKLDIRQ
LNENNFTVREIEILKGLSKSSVALKVKELNSNE
MKKANVLNLIRYHIEENDISFRKEARIIAEEFYKMGDDELAEYVLFMLRDANHFVPQIDQEYDIQIPFTQKIELERNSEP
LPLPQVISEEIKGVINAISKNRKINKFLFQGFPGTGKTETVKQIARILNRNLFMVDFNNLIDSHLGQSSKNIAELFQKIN
QTPNPKKIIICFDEIDALALDRTNKTDLREMGRVTTAVFQGLDKLDTDIIVFATTNLFKHFDKALIRRFDLVIDFNRYTK
KDMLDIAEIILKHYIKKVDNIKSELRLFRKIISLSEELIYPGDLKNIIKSSIYLSDYEDQYDYLKRIYKKITDDKLDIRQ
LNENNFTVREIEILKGLSKSSVALKVKELNSNE
Download Length: 1062 bp
>AT10046 NZ_CP001668:175482-176543 [Mycoplasma mycoides subsp. capri str. GM12]
ATGAAAAAGGCAAATGTTTTAAATTTAATTAGATATCACATAGAAGAAAATGACATATCTTTTAGAAAAGAAGCACGTAT
TATAGCTGAAGAATTTTACAAAATGGGTGATGATGAGTTAGCTGAATATGTTTTATTTATGTTAAGAGATGCAAATCATT
TTGTTCCACAAATAGATCAAGAGTATGATATTCAAATACCGTTTACTCAAAAAATAGAACTTGAAAGAAATAGTGAGCCT
TTACCACTTCCACAAGTTATAAGTGAAGAAATAAAAGGAGTTATTAATGCTATTAGTAAAAATAGAAAGATAAATAAGTT
TTTATTTCAAGGTTTTCCTGGAACTGGAAAAACTGAAACTGTAAAACAAATAGCAAGAATATTAAATAGAAATCTTTTTA
TGGTTGATTTTAATAATTTAATAGATTCTCATTTAGGTCAATCAAGTAAAAATATCGCTGAATTATTTCAAAAAATTAAT
CAAACTCCAAATCCAAAAAAAATTATTATCTGTTTTGATGAAATTGATGCTTTAGCTTTAGATAGAACAAACAAAACTGA
TCTAAGAGAAATGGGTAGAGTAACAACTGCTGTTTTTCAAGGGTTAGATAAACTAGATACTGATATTATTGTTTTTGCAA
CAACAAATCTCTTTAAACATTTTGATAAAGCTTTAATTAGAAGATTTGACCTTGTAATTGATTTTAATAGATACACAAAA
AAAGATATGTTAGATATAGCTGAAATTATATTAAAGCATTATATTAAAAAAGTAGATAACATTAAAAGTGAATTAAGATT
ATTTAGAAAAATTATTTCATTATCAGAAGAATTGATTTATCCTGGTGATTTAAAAAATATTATCAAATCAAGTATTTATT
TAAGTGATTATGAAGATCAATATGATTATTTAAAAAGGATTTATAAAAAGATAACTGATGATAAGCTTGACATTAGACAA
CTTAATGAAAACAATTTTACTGTACGAGAAATTGAAATTTTAAAAGGTTTATCAAAAAGTAGCGTAGCTCTGAAAGTGAA
GGAGTTAAATTCAAATGAATAA
ATGAAAAAGGCAAATGTTTTAAATTTAATTAGATATCACATAGAAGAAAATGACATATCTTTTAGAAAAGAAGCACGTAT
TATAGCTGAAGAATTTTACAAAATGGGTGATGATGAGTTAGCTGAATATGTTTTATTTATGTTAAGAGATGCAAATCATT
TTGTTCCACAAATAGATCAAGAGTATGATATTCAAATACCGTTTACTCAAAAAATAGAACTTGAAAGAAATAGTGAGCCT
TTACCACTTCCACAAGTTATAAGTGAAGAAATAAAAGGAGTTATTAATGCTATTAGTAAAAATAGAAAGATAAATAAGTT
TTTATTTCAAGGTTTTCCTGGAACTGGAAAAACTGAAACTGTAAAACAAATAGCAAGAATATTAAATAGAAATCTTTTTA
TGGTTGATTTTAATAATTTAATAGATTCTCATTTAGGTCAATCAAGTAAAAATATCGCTGAATTATTTCAAAAAATTAAT
CAAACTCCAAATCCAAAAAAAATTATTATCTGTTTTGATGAAATTGATGCTTTAGCTTTAGATAGAACAAACAAAACTGA
TCTAAGAGAAATGGGTAGAGTAACAACTGCTGTTTTTCAAGGGTTAGATAAACTAGATACTGATATTATTGTTTTTGCAA
CAACAAATCTCTTTAAACATTTTGATAAAGCTTTAATTAGAAGATTTGACCTTGTAATTGATTTTAATAGATACACAAAA
AAAGATATGTTAGATATAGCTGAAATTATATTAAAGCATTATATTAAAAAAGTAGATAACATTAAAAGTGAATTAAGATT
ATTTAGAAAAATTATTTCATTATCAGAAGAATTGATTTATCCTGGTGATTTAAAAAATATTATCAAATCAAGTATTTATT
TAAGTGATTATGAAGATCAATATGATTATTTAAAAAGGATTTATAAAAAGATAACTGATGATAAGCTTGACATTAGACAA
CTTAATGAAAACAATTTTACTGTACGAGAAATTGAAATTTTAAAAGGTTTATCAAAAAGTAGCGTAGCTCTGAAAGTGAA
GGAGTTAAATTCAAATGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Z7PM44 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Z7LB51 |
References
(1) Virginia Hill et al. (2021) Minimalistic mycoplasmas harbor different functional toxin-antitoxin systems. PLoS Genetics 17(10):e1009365. [PubMed:34673769]