Detailed information of TA system TA100453

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2153007..2153544
• Replicon: chromosome
• Accession: NZ_CP028108
• Organism: Fusobacterium periodonticum strain 2_1_31

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K1GXU3
• Locus tag: C4N17_RS10890
• Protein ID: WP_005966271.1
• Coordinates: 2153007..2153279 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: K1GRY6
• Locus tag: C4N17_RS10895
• Protein ID: WP_005966269.1
• Coordinates: 2153281..2153544 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4N17_RS10860	2148551..2149798	-	1248	WP_008793898.1	Fic family protein	-
C4N17_RS10865	2149892..2150890	-	999	WP_008793899.1	NAD-dependent epimerase/dehydratase family protein	-
C4N17_RS10870	2151141..2151623	+	483	WP_008793900.1	DUF1877 family protein	-
C4N17_RS10880	2152091..2152306	-	216	Protein_2029	DUF554 domain-containing protein	-
C4N17_RS10885	2152450..2152953	+	504	WP_008793902.1	YfbM family protein	-
C4N17_RS10890	2153007..2153279	-	273	WP_005966271.1	type II toxin-antitoxin system YafQ family toxin	Toxin
C4N17_RS10895	2153281..2153544	-	264	WP_005966269.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
C4N17_RS10900	2153681..2154190	-	510	WP_005966268.1	transcription repressor NadR	-
C4N17_RS10905	2154183..2155043	-	861	WP_008793903.1	carboxylating nicotinate-nucleotide diphosphorylase	-
C4N17_RS10910	2155021..2156313	-	1293	WP_008793904.1	L-aspartate oxidase	-
C4N17_RS10915	2156315..2157211	-	897	WP_008793905.1	quinolinate synthase NadA	-
C4N17_RS10920	2157495..2158106	-	612	WP_005966263.1	LysE family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10713.44 Da
• Isoelectric Point: 8.7818

>T100453 WP_005966271.1 NZ_CP028108:c2153279-2153007 [Fusobacterium periodonticum]
MYEIKTTTRFEKDLKLIKKRGYDTKLLKEVIDILSKGEKLEEKYKDHYLQGNYSGFKECHIKPDWLLVYKIEDNVLVLTL
SRTGTHSDLF

Nucleotide

• Length: 273 bp

>T100453 NZ_CP028108:c2153279-2153007 [Fusobacterium periodonticum]
ATGTATGAAATTAAAACCACAACTAGATTTGAAAAAGATTTAAAATTAATAAAAAAAAGAGGATACGATACAAAATTATT
AAAAGAAGTAATTGATATCTTATCTAAAGGAGAAAAATTAGAAGAAAAATATAAAGATCATTATTTACAAGGAAATTATT
CAGGATTTAAAGAGTGCCATATAAAACCTGATTGGTTACTTGTTTATAAGATTGAAGACAATGTTCTTGTATTAACACTT
TCAAGAACAGGGACACATTCGGATTTGTTTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9860.41 Da
• Isoelectric Point: 4.5348

>AT100453 WP_005966269.1 NZ_CP028108:c2153544-2153281 [Fusobacterium periodonticum]
MAVINIRVNDEVKKEAETIFKALGLNMSVAMNLFLKKCINENGIPFDLKVPNKETIEAMEETNKILNGDIERKSYKNADE
LFEDLGV

Nucleotide

• Length: 264 bp

>AT100453 NZ_CP028108:c2153544-2153281 [Fusobacterium periodonticum]
ATGGCTGTTATAAATATTCGTGTTAATGATGAAGTAAAGAAAGAGGCTGAAACTATTTTTAAGGCTTTAGGTCTTAATAT
GTCAGTTGCAATGAATTTATTTTTAAAAAAATGTATAAATGAAAATGGAATTCCATTTGATTTAAAGGTTCCAAATAAAG
AAACAATAGAAGCAATGGAAGAGACTAATAAGATATTAAATGGAGATATAGAAAGAAAATCATATAAAAATGCTGATGAG
TTATTTGAAGATTTAGGTGTGTAA

Structures

Toxin

• AlphaFold DB: A0A095WF67

Antitoxin

• AlphaFold DB: A0A2D3NZ60