100452

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 1922263..1922770 Replicon chromosome
Accession NZ_CP028108
Organism Fusobacterium periodonticum strain 2_1_31

Toxin (Protein)


Gene name yoeB Uniprot ID A0A095WFS9
Locus tag C4N17_RS09605 Protein ID WP_008794772.1
Coordinates 1922263..1922523 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID U7TRN8
Locus tag C4N17_RS09610 Protein ID WP_005892688.1
Coordinates 1922516..1922770 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4N17_RS09580 1918552..1918938 - 387 WP_008794776.1 Fe-S cluster assembly scaffold protein NifU -
C4N17_RS09585 1919011..1920204 - 1194 WP_008794775.1 cysteine desulfurase NifS -
C4N17_RS09590 1920284..1920934 - 651 WP_005966059.1 endonuclease III -
C4N17_RS09595 1921236..1921721 - 486 WP_081928107.1 GNAT family N-acetyltransferase -
C4N17_RS09600 1921750..1922253 - 504 WP_008794773.1 GNAT family N-acetyltransferase -
C4N17_RS09605 1922263..1922523 - 261 WP_008794772.1 Txe/YoeB family addiction module toxin Toxin
C4N17_RS09610 1922516..1922770 - 255 WP_005892688.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C4N17_RS09615 1923012..1923446 - 435 WP_035467995.1 hypothetical protein -
C4N17_RS09620 1923470..1923910 - 441 WP_187145646.1 hypothetical protein -
C4N17_RS09625 1923970..1925346 - 1377 WP_008794771.1 hypothetical protein -
C4N17_RS09630 1925542..1926087 - 546 WP_005966068.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10265.87 Da        Isoelectric Point: 9.6577

>T100452 WP_008794772.1 NZ_CP028108:c1922523-1922263 [Fusobacterium periodonticum]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIERNGVLKGIGKPEVLKNESAYSRRIDEKNRLVYRIVDGFILIIAC
KGHYEE

Download         Length: 261 bp

>T100452 NZ_CP028108:c1922523-1922263 [Fusobacterium periodonticum]
ATGAATAATTTGGTATGGACGCATAAGGCTTGGCAAGATTACTTATATTGGCAAACTCAGGATAAAAAAACTTTGAAAAA
GATAAATGAATTAGTCAAAGATATTGAAAGAAATGGAGTTTTAAAAGGAATAGGCAAGCCAGAAGTATTAAAAAATGAAA
GTGCATACAGTAGAAGAATTGATGAAAAAAATAGACTGGTTTATAGAATTGTAGATGGTTTTATATTGATAATTGCTTGT
AAAGGTCATTATGAGGAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9824.17 Da        Isoelectric Point: 4.4453

>AT100452 WP_005892688.1 NZ_CP028108:c1922770-1922516 [Fusobacterium periodonticum]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Download         Length: 255 bp

>AT100452 NZ_CP028108:c1922770-1922516 [Fusobacterium periodonticum]
ATGTTAGCAATTAATTATACAACTTTGAGAACCAATTTAAAAAGCTATTTTGATAAAGCAGTTGATAATGATGAAGATAT
TATTATAACAAGAAAAAATGAGAGAAATGTTGTTCTATTAAGTCTTGATAAATATAATGAGTTTTTAAAAGCTATGAGGA
ATCTTGAATATATGACAAAAATAAGAGAAGGAATAGCTGAATTAGAAGCAGGAAAAGGAGAAATTCATGATTTAATAGAG
GTTGATGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A095WFS9

Antitoxin

Source ID Structure
AlphaFold DB A0A806UAF3

References