Detailed information of TA system TA100450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 110224..110723
• Replicon: chromosome
• Accession: NZ_CP028106
• Organism: Fusobacterium gonidiaformans ATCC 25563

Toxin (Protein)

• Gene name: relE
• Uniprot ID: E5BHE0
• Locus tag: C4N16_RS00585
• Protein ID: WP_008801981.1
• Coordinates: 110224..110496 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E5BHE1
• Locus tag: C4N16_RS00590
• Protein ID: WP_008801982.1
• Coordinates: 110493..110723 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4N16_RS00555	105444..106391	-	948	WP_010680494.1	signal peptidase I	-
C4N16_RS00560	106512..106862	-	351	WP_008801976.1	50S ribosomal protein L19	-
C4N16_RS00565	107037..107492	+	456	WP_008801977.1	hypothetical protein	-
C4N16_RS00570	107729..108730	+	1002	WP_010680493.1	ATP-binding cassette domain-containing protein	-
C4N16_RS00575	108720..109370	+	651	WP_010680492.1	ABC transporter permease	-
C4N16_RS00580	109394..110170	+	777	WP_082161493.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
C4N16_RS00585	110224..110496	-	273	WP_008801981.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C4N16_RS00590	110493..110723	-	231	WP_008801982.1	hypothetical protein	Antitoxin
C4N16_RS00595	110825..111343	+	519	WP_147366518.1	hypothetical protein	-
C4N16_RS00600	111229..112047	-	819	WP_010680490.1	metal ABC transporter permease	-
C4N16_RS00605	112034..112681	-	648	WP_010680489.1	ATP-binding cassette domain-containing protein	-
C4N16_RS00610	112691..113656	-	966	WP_010680488.1	metal ABC transporter substrate-binding protein	-
C4N16_RS00615	113725..114414	-	690	WP_010680487.1	SDR family oxidoreductase	-
C4N16_RS00620	114411..115421	-	1011	WP_039991453.1	deoxyribodipyrimidine photo-lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-72)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10861.75 Da
• Isoelectric Point: 10.6934

>T100450 WP_008801981.1 NZ_CP028106:c110496-110224 [Fusobacterium gonidiaformans ATCC 25563]
MRYQVEFSQQGKKELKKLDAFAQKIIMKWISKNLINTENPRIHGKELKGNLKSFWRYRVGNYRLLADIQDENITILLIKI
GHRREIYDKK

Nucleotide

• Length: 273 bp

>T100450 NZ_CP028106:c110496-110224 [Fusobacterium gonidiaformans ATCC 25563]
ATGAGATACCAAGTAGAATTTTCACAACAAGGAAAAAAAGAACTCAAAAAACTAGATGCTTTTGCTCAGAAAATTATTAT
GAAATGGATTTCTAAAAATTTAATAAATACAGAAAATCCAAGAATACATGGCAAAGAATTAAAGGGAAATTTAAAATCAT
TTTGGAGATATCGTGTTGGAAATTATAGGCTATTAGCAGATATCCAAGATGAAAATATAACTATTTTACTCATTAAGATC
GGGCATAGAAGAGAAATTTATGATAAAAAATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9029.19 Da
• Isoelectric Point: 4.1255

>AT100450 WP_008801982.1 NZ_CP028106:c110723-110493 [Fusobacterium gonidiaformans ATCC 25563]
MSVISLRLNEKEEKLLKEFSEFEGLGISSYIKKIIYERLEDEYDIQCFDKAYEEYLESGKKSYSFDEVLNELGIEL

Nucleotide

• Length: 231 bp

>AT100450 NZ_CP028106:c110723-110493 [Fusobacterium gonidiaformans ATCC 25563]
ATGTCTGTTATTTCCTTGAGATTAAATGAGAAAGAAGAAAAATTATTAAAAGAATTTTCAGAATTTGAGGGCTTAGGTAT
TTCCTCGTATATAAAGAAAATTATTTATGAGCGATTAGAGGACGAATATGATATTCAATGTTTTGATAAAGCTTATGAAG
AATATTTGGAAAGTGGAAAAAAATCTTATTCTTTTGATGAAGTTTTAAATGAATTGGGAATTGAATTATGA

Structures

Toxin

• AlphaFold DB: E5BHE0

Antitoxin

• AlphaFold DB: E5BHE1