Detailed information of TA system TA100449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1956932..1957491
• Replicon: chromosome
• Accession: NZ_CP028102
• Organism: Fusobacterium mortiferum ATCC 9817

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C4N19_RS09760
• Protein ID: WP_106991842.1
• Coordinates: 1956932..1957204 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C4N19_RS09765
• Protein ID: WP_005885408.1
• Coordinates: 1957210..1957491 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4N19_RS09720	1952479..1953912	-	1434	WP_005885419.1	recombinase family protein	-
C4N19_RS09725	1954139..1954354	-	216	WP_005885417.1	hypothetical protein	-
C4N19_RS09730	1954357..1954602	-	246	WP_005885416.1	hypothetical protein	-
C4N19_RS09735	1954571..1954996	-	426	WP_005885414.1	hypothetical protein	-
C4N19_RS09740	1954997..1955488	-	492	WP_005885412.1	hypothetical protein	-
C4N19_RS09745	1955488..1955682	-	195	WP_005885411.1	hypothetical protein	-
C4N19_RS09750	1955836..1956351	-	516	WP_005885410.1	Rha family transcriptional regulator	-
C4N19_RS09755	1956595..1956771	-	177	WP_147366712.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
C4N19_RS09760	1956932..1957204	-	273	WP_106991842.1	type II toxin-antitoxin system YafQ family toxin	Toxin
C4N19_RS09765	1957210..1957491	-	282	WP_005885408.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
C4N19_RS09770	1957603..1957863	-	261	WP_005885406.1	hypothetical protein	-
C4N19_RS09775	1957899..1958882	-	984	WP_005885404.1	recombinase RecT	-
C4N19_RS09780	1959288..1960415	-	1128	WP_005885402.1	YqaJ viral recombinase family protein	-
C4N19_RS09785	1960650..1960829	-	180	WP_005885401.1	hypothetical protein	-
C4N19_RS13530	1960936..1961073	-	138	WP_005885399.1	hypothetical protein	-
C4N19_RS09790	1961358..1962050	+	693	WP_005885398.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1942977..2010808	67831

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10640.49 Da
• Isoelectric Point: 9.3103

>T100449 WP_106991842.1 NZ_CP028102:c1957204-1956932 [Fusobacterium mortiferum ATCC 9817]
MLEIITTSAFDKDYKLLKKRGYNLKLLQEVVEKLANEEVLPAKYRNHQLIGNYVGYMECHIRPDWLLIYKIEKNKLILTL
SRTGTHSDLF

Nucleotide

• Length: 273 bp

>T100449 NZ_CP028102:c1957204-1956932 [Fusobacterium mortiferum ATCC 9817]
ATGTTAGAAATCATAACTACTAGTGCTTTTGATAAAGATTATAAACTTTTAAAAAAAAGGGGATATAATCTCAAGCTTCT
TCAAGAAGTCGTTGAAAAATTAGCAAATGAAGAAGTGTTACCAGCTAAGTATAGAAATCATCAATTAATTGGAAATTATG
TAGGATACATGGAGTGCCATATTCGTCCTGATTGGTTATTAATATATAAAATTGAAAAAAATAAATTAATCCTAACTTTA
TCAAGAACAGGAACTCATAGTGATTTATTTTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10620.10 Da
• Isoelectric Point: 4.5498

>AT100449 WP_005885408.1 NZ_CP028102:c1957491-1957210 [Fusobacterium mortiferum ATCC 9817]
MGVSVINVRLDDEDKKAFNELCNELGLNMSTAFNMFVKSMLRTGGLPFEARIENYNVETIKAIQETEDIINGKVKRPTYK
NTKELFDALDKED

Nucleotide

• Length: 282 bp

>AT100449 NZ_CP028102:c1957491-1957210 [Fusobacterium mortiferum ATCC 9817]
ATGGGAGTATCAGTTATTAATGTAAGATTAGATGATGAAGATAAAAAAGCCTTTAATGAGTTATGTAATGAGTTAGGTTT
AAATATGTCAACAGCTTTTAATATGTTTGTCAAATCTATGCTTAGAACAGGTGGATTACCATTTGAGGCAAGAATAGAAA
ACTATAATGTTGAAACTATAAAAGCTATTCAAGAAACAGAAGATATTATCAATGGAAAAGTAAAACGTCCTACTTATAAA
AATACCAAAGAACTTTTTGATGCTCTTGATAAGGAGGATTAA